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Location: Sioux Falls Synced from ClinicalTrials.gov · August 07, 2026

Clinical studies recruiting near Sioux Falls

Studies with at least one listed site matching this location on the public registry. Each page explains the study in plain language, with locations and study-team contacts. Clinicians: generate a printable list for your patient →

Study of Trastuzumab Deruxtecan Versus Standard of Care Chemotherapy for HER2-Expressing (IHC 3+/2+) Endometrial Cancer
Phase 3 · Avera Medical Group Gynecologic Oncology Sioux Falls · Daiichi Sankyo · NCT07022483
MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Wi
Phase 2 · Sanford Cancer Center Oncology Clinic · National Cancer Institute (NCI) · NCT05564390
A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) G
Phase 1/Phase 2 · Sanford USD Medical Center - Sioux Falls · National Cancer Institute (NCI) · NCT05099003
Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed
Phase 3 · Sanford USD Medical Center - Sioux Falls · National Cancer Institute (NCI) · NCT06172296
Testing the Addition of High Dose, Targeted Radiation to the Usual Treatment for Locally-Advanced Inoperable Non-Small C
Phase 3 · Sanford Cancer Center Oncology Clinic · NRG Oncology · NCT05624996
Testing the Addition of Anti-Cancer Drug Sonrotoclax, to the Standard Treatment Zanubrutinib, for Previously Untreated C
Phase 3 · Sanford Cancer Center Oncology Clinic · Alliance for Clinical Trials in Oncology · NCT07321652
A Study of Lower Radiotherapy Dose to Treat Children With CNS Germinoma
Phase 2 · Sanford USD Medical Center - Sioux Falls · Children's Oncology Group · NCT06368817
A Study to Test the Addition of the Drug Cabozantinib to Chemotherapy in Patients With Newly Diagnosed Osteosarcoma
Phase 2/Phase 3 · Sanford USD Medical Center - Sioux Falls · National Cancer Institute (NCI) · NCT05691478
A Study of Combination Chemotherapy for Patients With Newly Diagnosed DAWT and Relapsed FHWT
Phase 2 · Sanford USD Medical Center - Sioux Falls · Children's Oncology Group · NCT04322318
Using Biomarker Tests to Select and Test New, Personalized Treatments for Extensive Stage Small Cell Lung Cancer, PRISM
Phase 2 · Sanford Cancer Center Oncology Clinic · SWOG Cancer Research Network · NCT06769126
Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With High Risk Prostate Cancer
Phase 3 · Sanford USD Medical Center - Sioux Falls · NRG Oncology · NCT05946213
Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease
Phase 2/Phase 3 · Sanford Cancer Center Oncology Clinic · NRG Oncology · NCT05174169
Comparing Impact of Treatment Before or After Surgery in Patients With Stage II-IIIB Resectable Non-small Cell Lung Canc
Phase 3 · Sanford Cancer Center Oncology Clinic · Alliance for Clinical Trials in Oncology · NCT06632327
Testing the Addition of Docetaxel (Chemotherapy) to the Usual Treatment (Hormonal Therapy and Apalutamide) for Metastati
Phase 3 · Sanford Cancer Center Oncology Clinic · Alliance for Clinical Trials in Oncology · NCT06931340
ShortStop-HER2: 12 Months vs. 6 Months of HER2-targeted Medications for People With HER2+ Breast Cancer Who Had a Pathol
Phase 3 · Sanford Cancer Center Oncology Clinic · Alliance for Clinical Trials in Oncology · NCT06876714
A Study of Brenipatide in Participants With Opioid Use Disorder
Phase 2 · Avera Research Institute - Sioux Falls · Eli Lilly and Company · NCT07420283
Investigation of Ubamatamab Combination Therapy in Adult Participants With Platinum-Resistant Ovarian Cancer
Phase 2 · Avera Cancer Institute Sioux Falls · Regeneron Pharmaceuticals · NCT06787612
A Study to Compare Standard Chemotherapy to Therapy With CPX-351 and/or Gilteritinib for Patients With Newly Diagnosed A
Phase 3 · Sanford USD Medical Center - Sioux Falls · Children's Oncology Group · NCT04293562
E-Mindfulness Approaches for Living After Breast Cancer
Phase 3 · Sanford Cancer Center Oncology Clinic · NRG Oncology · NCT06748222
Collection of Research Data and Samples From Patients Who Experience Immunotherapy Side Effects
Phase N/A · Sanford Cancer Center Oncology Clinic · Alliance for Clinical Trials in Oncology · NCT04242095
EPIC-Peds: A Study to Learn About the Study Medicine Called PF-07321332 (Nirmatrelvir)/Ritonavir in Patients Under 18 Ye
Phase 3 · Avera McKennan Hospital & University Health Center · Pfizer · NCT05261139
Testing the Addition of Herceptin Hylecta or Phesgo to the Usual Chemotherapy for HER2 Positive Endometrial Serous Carci
Phase 3 · Sanford Cancer Center Oncology Clinic · National Cancer Institute (NCI) · NCT05256225
Immunotherapy After Surgery for People Who Have No Remaining Cancer Cells After Standard Treatment for Early-Stage Non-S
Phase 3 · Sanford Cancer Center Oncology Clinic · National Cancer Institute (NCI) · NCT06498635
Project: Every Child for Younger Patients With Cancer
Phase N/A · Sanford USD Medical Center - Sioux Falls · Children's Oncology Group · NCT02402244
Combining Immunotherapy and Radiation Therapy to Help Patients Avoid Bladder Removal After Treatment Shrinks Muscle Inva
Phase 2 · Sanford Cancer Center Oncology Clinic · National Cancer Institute (NCI) · NCT07061964
Testing the Addition of Stereotactic Radiation Therapy With Immune Therapy for the Treatment of Patients With Unresectab
Phase 2 · Sanford Cancer Center Oncology Clinic · NRG Oncology · NCT05327686
Thoracotomy Versus Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma
Phase 3 · Sanford USD Medical Center - Sioux Falls · Children's Oncology Group · NCT05235165
De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Eq
Phase 3 · Sanford Cancer Center Oncology Clinic · NRG Oncology · NCT04852887
Myopenia and Mechanisms of Chemotherapy Toxicity in Older Adults With Colorectal Cancer
Phase N/A · Sanford Cancer Center Oncology Clinic · Wake Forest University Health Sciences · NCT03998202
mFOLFIRINOX Versus mFOLFOX With or Without Nivolumab for the Treatment of Advanced, Unresectable, or Metastatic HER2 Neg
Phase 3 · Sanford Cancer Center Oncology Clinic · Alliance for Clinical Trials in Oncology · NCT05677490
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