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Study identifier: NCT05946213 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With High Risk Prostate Cancer

Condition: Prostate Adenocarcinoma · Stage III Prostate Cancer AJCC v8 · Stage IVA Prostate Cancer AJCC v8  ·  Sponsor: NRG Oncology

PhasePhase 3
Planned participants1209
Who can joinMale, 18 Years to no upper limit
Healthy volunteersNo

About this study

This phase III trial compares stereotactic body radiation therapy (SBRT), (five treatments over two weeks using a higher dose per treatment) to usual radiation therapy (20 to 45 treatments over 4 to 9 weeks) for the treatment of high-risk prostate cancer. SBRT uses special equipment to position a patient and deliver radiation to tumors with high precision. This method may kill tumor cells with fewer doses over a shorter period of time. This trial is evaluating if shorter duration radiation prevents cancer from coming back as well as the usual radiation treatment.

This description comes directly from the study's public registry record.

Talk to the study team

Contact details are listed per location below or on the registry record.

Always discuss trial participation with your own doctor first.

Locations (413)

University of Alabama at Birmingham Cancer CenterBirmingham, Alabama, United StatesRecruiting
The Kirklin Clinic at Acton RoadBirmingham, Alabama, United StatesRecruiting
Lewis and Faye Manderson Cancer CenterTuscaloosa, Alabama, United StatesRecruiting
University of Arkansas for Medical SciencesLittle Rock, Arkansas, United StatesRecruiting
Kaiser Permanente-Deer Valley Medical CenterAntioch, California, United StatesRecruiting
Tower Cancer Research FoundationBeverly Hills, California, United StatesRecruiting
Kaiser Permanente DublinDublin, California, United StatesRecruiting
Kaiser Permanente-FremontFremont, California, United StatesRecruiting
Washington HospitalFremont, California, United StatesRecruiting
Fresno Cancer CenterFresno, California, United StatesRecruiting
Kaiser Permanente Fresno Orchard PlazaFresno, California, United StatesRecruiting
Kaiser Permanente-FresnoFresno, California, United StatesRecruiting

+ 401 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05946213