Condition: Extensive Stage Lung Small Cell Carcinoma · Lung Small Cell Carcinoma, A Subtype · Lung Small Cell Carcinoma, I Subtype · Sponsor: SWOG Cancer Research Network
This phase II trial tests how well biomarker tests on patients tumor tissue works in selecting personalized treatments for patients with extensive stage small cell lung cancer (ES-SCLC). Biomarker tests look for certain features in cancer cells that may give doctors more information about what is driving cancer and how to treat it. Based on the biomarker test results, study doctors can determine the subtype of ES-SCLC that study treatments can target. This study also tests different types of maintenance treatment for ES-SCLC with drugs durvalumab, saruparib, ceralasertib or monalizumab. Maintenance treatment is given after initial treatment and is given to help keep the cancer under control and prevent it from getting worse. Immunotherapy with monoclonal antibodies, such as durvalumab and monalizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Saruparib is a PARP inhibitor. PARP is a protein that helps repair damaged deoxyribonucleic acid (DNA). Blocking PARP may prevent cancer cells from repairing their damaged DNA, causing them to die. PARP inhibitors are a type of targeted therapy. Ceralasertib may stop the growth of tumor cells and may kill them by blocking some of the enzymes needed for tumor cell growth. Giving biomarker selected personalized maintenance treatment with durvalumab, saruparib, ceralasertib or monalizumab may work better in treating patients with ES-SCLC.
This description comes directly from the study's public registry record.
Contact details are listed per location below or on the registry record.
Always discuss trial participation with your own doctor first.
| Loma Linda University Medical Center | Loma Linda, California, United States | Recruiting |
| Eisenhower Medical Center | Rancho Mirage, California, United States | Recruiting |
| University of California Davis Comprehensive Cancer Center | Sacramento, California, United States | Recruiting |
| UCHealth University of Colorado Hospital | Aurora, Colorado, United States | Recruiting |
| UCHealth Memorial Hospital Central | Colorado Springs, Colorado, United States | Recruiting |
| Memorial Hospital North | Colorado Springs, Colorado, United States | Recruiting |
| Poudre Valley Hospital | Fort Collins, Colorado, United States | Recruiting |
| Cancer Care and Hematology-Fort Collins | Fort Collins, Colorado, United States | Recruiting |
| Lutheran Hospital - Cancer Centers of Colorado | Golden, Colorado, United States | Recruiting |
| UCHealth Greeley Hospital | Greeley, Colorado, United States | Recruiting |
| Medical Center of the Rockies | Loveland, Colorado, United States | Recruiting |
| Smilow Cancer Hospital-Derby Care Center | Derby, Connecticut, United States | Recruiting |
+ 136 more locations — full list on the registry record.
Get one email when the public record changes — results posted, or the study's status changes. Nothing else, ever.
We email about this public record only. Unsubscribe anytime with one click. Never medical advice.
This page is independently generated by Eichor from the public ClinicalTrials.gov record and re-synced daily. It is not the sponsor's official website unless claimed. Nothing here is medical advice; eligibility is always determined by the study team — talk to your own doctor first.
Source record: clinicaltrials.gov/study/NCT06769126