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Study identifier: NCT06498635 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Immunotherapy After Surgery for People Who Have No Remaining Cancer Cells After Standard Treatment for Early-Stage Non-Small Cell Lung Cancer, INSIGHT Trial

Condition: Lung Non-Small Cell Carcinoma · Stage II Lung Cancer AJCC v8 · Stage IIIA Lung Cancer AJCC v8  ·  Sponsor: National Cancer Institute (NCI)

PhasePhase 3
Planned participants306
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This phase III trial compares durvalumab to the usual approach (patient observation) after surgery for the treatment of patients with early-stage non-small cell lung cancer. Immunotherapy with monoclonal antibodies, such as durvalumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. The usual approach for patients who are not in a study is to closely watch a patient's condition after surgery and to have regular visits with their doctor to watch for signs of the cancer coming back. Usually, patients do not receive further treatment unless the cancer returns. This study will help determine whether this different approach with durvalumab is better, the same, or worse than the usual approach of observation. Giving durvalumab may help patients live longer and prevent early-stage non-small cell lung cancer from coming back as compared to the usual approach.

This description comes directly from the study's public registry record.

Talk to the study team

Contact details are listed per location below or on the registry record.

Always discuss trial participation with your own doctor first.

Locations (266)

NEA Baptist Memorial Hospital and Fowler Family Cancer Center - JonesboroJonesboro, Arkansas, United StatesRecruiting
Tower Cancer Research FoundationBeverly Hills, California, United StatesRecruiting
Kaiser Permanente DublinDublin, California, United StatesRecruiting
Kaiser Permanente-FremontFremont, California, United StatesRecruiting
Kaiser Permanente Fresno Orchard PlazaFresno, California, United StatesRecruiting
UC San Diego Moores Cancer CenterLa Jolla, California, United StatesRecruiting
Veterans Affairs Loma Linda Healthcare SystemLoma Linda, California, United StatesRecruiting
Cedars-Sinai Medical CenterLos Angeles, California, United StatesRecruiting
Kaiser Permanente- Modesto MOB IIModesto, California, United StatesRecruiting
Kaiser Permanente-OaklandOakland, California, United StatesRecruiting
Kaiser Permanente-RosevilleRoseville, California, United StatesRecruiting
Kaiser Permanente Downtown CommonsSacramento, California, United StatesRecruiting

+ 254 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06498635