Condition: Anatomic Stage I Breast Cancer AJCC v8 · Anatomic Stage II Breast Cancer AJCC v8 · Early Stage HER2+ Breast Cancer · Sponsor: Alliance for Clinical Trials in Oncology
This phase III trial compares 6 months of human epidermal growth factor receptor 2 (HER2)-targeted therapy to 12 months of HER2-targeted therapy for the treatment of HER2-positive (+) breast cancer in patients that had a pathologic complete response (pCR) after preoperative (neoadjuvant) chemotherapy with trastuzumab. Trastuzumab and pertuzumab are monoclonal antibodies and forms of targeted therapy that attach to a receptor protein called HER2. HER2 is found on some cancer cells. When trastuzumab or pertuzumab attach to HER2, the signals that tell the cells to grow are blocked and the tumor cell may be marked for destruction by the body's immune system. Giving 6 months of HER2-targeted therapy may work better than giving 12 months for the treatment of HER2+ breast cancer in patients that had a pCR after neoadjuvant chemotherapy with trastuzumab.
This description comes directly from the study's public registry record.
Jack Beranek · 773-702-9171 · breastprotocols@alliancenctn.org
Always discuss trial participation with your own doctor first.
| Cancer Center at Saint Joseph's | Phoenix, Arizona, United States | Suspended |
| Mayo Clinic Hospital in Arizona | Phoenix, Arizona, United States | Recruiting |
| Mercy Hospital Fort Smith | Fort Smith, Arkansas, United States | Suspended |
| NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro | Jonesboro, Arkansas, United States | Recruiting |
| CARTI Cancer Center | Little Rock, Arkansas, United States | Suspended |
| Mission Hope Medical Oncology - Arroyo Grande | Arroyo Grande, California, United States | Suspended |
| Tower Cancer Research Foundation | Beverly Hills, California, United States | Recruiting |
| Mercy Cancer Center - Carmichael | Carmichael, California, United States | Recruiting |
| Mercy San Juan Medical Center | Carmichael, California, United States | Recruiting |
| Enloe Medical Center | Chico, California, United States | Recruiting |
| Kaiser Permanente Dublin | Dublin, California, United States | Recruiting |
| Mercy Cancer Center - Elk Grove | Elk Grove, California, United States | Recruiting |
+ 659 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06876714