Condition: Locally Advanced Lung Non-Small Cell Carcinoma · Stage IIB Lung Cancer AJCC v8 · Stage III Lung Cancer AJCC v8 · Sponsor: NRG Oncology
This phase III trial compares the effect of adding stereotactic body radiation therapy (SBRT) to the usual treatment (conventional image guided radiation therapy \[IGRT\] and chemotherapy followed by immunotherapy with durvalumab or targeted therapy with osimertinib) versus the usual treatment alone in treating patients with non-small cell lung cancer that has spread to nearby tissue or lymph nodes (locally advanced) and cannot be treated by surgery (inoperable). SBRT uses special equipment to position a patient and deliver radiation therapy to tumors with high precision. This method may kill tumor cells with fewer doses over a shorter period and cause less damage to normal tissue. IGRT is a type of radiation therapy that creates a picture of the tumor to help guide the radiation beam during therapy, making it more accurate and causing less damage to healthy tissue. Usual chemotherapy used in this trial consists of combinations of the following drugs: cisplatin, carboplatin, paclitaxel, nab-paclitaxel, pemetrexed, and etoposide. Cisplatin and carboplatin are in a class of medications known as platinum-containing compounds. Cisplatin works by killing, stopping, or slowing the growth of tumor cells. Carboplatin works in a way similar to the anticancer drug cisplatin but may be better tolerated than cisplatin. Carboplatin works by killing, stopping, or slowing the growth of tumor cells as well. Paclitaxel is in a class of medications called antimicrotubule agents. It works by st…
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Contact details are listed per location below or on the registry record.
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| University of Alabama at Birmingham Cancer Center | Birmingham, Alabama, United States | Recruiting |
| The Kirklin Clinic at Acton Road | Birmingham, Alabama, United States | Recruiting |
| Gulf Health Hospitals Inc/Infirmary Cancer Care - Malbis | Daphne, Alabama, United States | Recruiting |
| Thomas Hospital | Fairhope, Alabama, United States | Recruiting |
| Mobile Infirmary Medical Center | Mobile, Alabama, United States | Recruiting |
| Gulf Health Hospitals Inc/Infirmary Cancer Care - Saraland | Saraland, Alabama, United States | Recruiting |
| Kingman Regional Medical Center | Kingman, Arizona, United States | Recruiting |
| Cancer Center at Saint Joseph's | Phoenix, Arizona, United States | Recruiting |
| Mayo Clinic Hospital in Arizona | Phoenix, Arizona, United States | Recruiting |
| Banner University Medical Center - Tucson | Tucson, Arizona, United States | Recruiting |
| University of Arizona Cancer Center-North Campus | Tucson, Arizona, United States | Recruiting |
| NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro | Jonesboro, Arkansas, United States | Recruiting |
+ 465 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT05624996