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Study identifier: NCT04852887 Synced from ClinicalTrials.gov · August 02, 2026
● Recruiting

De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)

Condition: Stage I Breast Cancer  ·  Sponsor: NRG Oncology

PhasePhase 3
Planned participants1670
Who can joinAll sexes, 50 Years to 70 Years
Healthy volunteersNo

About this study

This Phase III Trial evaluates whether breast conservation surgery and endocrine therapy results in a non-inferior rate of invasive or non-invasive ipsilateral breast tumor recurrence (IBTR) compared to breast conservation with breast radiation and endocrine therapy.

This description comes directly from the study's public registry record.

Talk to the study team

Director Department of Regulatory Affairs  ·  412-339-5300  ·  langerj@nrgoncology.org

Norman Wolmark, MD

Always discuss trial participation with your own doctor first.

Locations (832)

University of Alabama at Birmingham Cancer CenterBirmingham, Alabama, United StatesActive Not Recruiting
University of South Alabama Mitchell Cancer InstituteMobile, Alabama, United StatesRecruiting
Kingman Regional Medical CenterKingman, Arizona, United StatesRecruiting
Cancer Center at Saint Joseph'sPhoenix, Arizona, United StatesRecruiting
Mayo Clinic Hospital in ArizonaPhoenix, Arizona, United StatesActive Not Recruiting
University of Arkansas for Medical SciencesLittle Rock, Arkansas, United StatesRecruiting
Kaiser Permanente-AnaheimAnaheim, California, United StatesRecruiting
Kaiser Permanente-Deer Valley Medical CenterAntioch, California, United StatesRecruiting
Mission Hope Medical Oncology - Arroyo GrandeArroyo Grande, California, United StatesRecruiting
PCR OncologyArroyo Grande, California, United StatesRecruiting
Sutter Auburn Faith HospitalAuburn, California, United StatesRecruiting
Sutter Cancer Centers Radiation Oncology Services-AuburnAuburn, California, United StatesRecruiting

+ 820 more locations — full list on the registry record.

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