Condition: Chronic Lymphocytic Leukemia · Small Lymphocytic Leukemia · Sponsor: Alliance for Clinical Trials in Oncology
This phase III trial compares the effect of adding sonrotoclax to zanubrutinib versus zanubrutinib alone for the treatment of patients with untreated chronic lymphoblastic leukemia (CLL)/small lymphocytic lymphoma (SLL). Sonrotoclax is in a class of medications called B-cell lymphoma-2 (BCL-2) inhibitors. It may stop the growth of cancer cells by blocking Bcl-2, a protein needed for cancer cell survival. Zanubrutinib is in a class of medications called kinase inhibitors. It blocks a protein called BTK, which is present on B-cell (a type of white blood cells) cancers such as mantel cell lymphoma at abnormal levels. This may help keep cancer cells from growing and spreading. Giving sonrotoclax and zanubrutinib may be more effective than zanubrutinib alone for the treatment of untreated CLL/SLL.
This description comes directly from the study's public registry record.
Jayke Giese · 773-702-9171 · leukemiaprotocols@alliancenctn.org
Always discuss trial participation with your own doctor first.
| Cedars-Sinai Medical Center | Los Angeles, California, United States | Recruiting |
| Jupiter Medical Center | Jupiter, Florida, United States | Recruiting |
| Saint Alphonsus Cancer Care Center-Boise | Boise, Idaho, United States | Recruiting |
| Saint Alphonsus Cancer Care Center-Caldwell | Caldwell, Idaho, United States | Recruiting |
| Kootenai Health - Coeur d'Alene | Coeur d'Alene, Idaho, United States | Recruiting |
| Idaho Urologic Institute-Meridian | Meridian, Idaho, United States | Recruiting |
| Saint Alphonsus Cancer Care Center-Nampa | Nampa, Idaho, United States | Recruiting |
| Kootenai Clinic Cancer Services - Post Falls | Post Falls, Idaho, United States | Recruiting |
| Kootenai Clinic Cancer Services - Sandpoint | Sandpoint, Idaho, United States | Recruiting |
| Illinois CancerCare-Bloomington | Bloomington, Illinois, United States | Recruiting |
| Illinois CancerCare-Canton | Canton, Illinois, United States | Recruiting |
| Illinois CancerCare-Carthage | Carthage, Illinois, United States | Recruiting |
+ 140 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT07321652