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Condition: Major Depression Severe Synced from ClinicalTrials.gov · August 08, 2026

Recruiting studies: Major Depression Severe

Studies currently listed as recruiting on the public registry for this search term. Each page explains the study in plain language, with locations and the study team's contact details. Clinicians: generate a printable list for your patient →

Effect of Psilocybin and Structured Integrated Reframing Therapy on Gut-Brain Axis Biomarkers and Depression in Major De
Phase 3 · 3 location(s) · Khyber Medical University Peshawar · NCT07703722
Brain Imaging of Cognition Inn Schizophrenia and Depression
Phase N/A · 1 location(s) · The Royal Ottawa Mental Health Centre · NCT04159662
Efficacy of Statins Among Major Depressive Disorder
Phase 3 · 1 location(s) · Ain Shams University · NCT06698666
Stratified Pharmacological Approaches for Regulating Circuit-Level Effects
Phase 2 · 1 location(s) · Stanford University · NCT07022405
Comparing the Efficacy of fMRI-Guided vs. Standard iTBS in Treating Depression
NA · 1 location(s) · The Royal Ottawa Mental Health Centre · NCT06152705
A Mechanistic Study to Assess a Single Dose of CYB003 in Participants With Depression and Anxiety
Phase 2 · 1 location(s) · Ohio State University · NCT06820723
Near Infrared Spectroscopy (NIRS) for Assessment of Depression
NA · 1 location(s) · University of California, San Francisco · NCT04061148
ipRGC as a Potential Biomarker for Predicting Transcranial Magnetic Stimulation Treatment Response in Major Depressive D
NA · 1 location(s) · Polytechnic Institute of Porto · NCT07474974
Targeting Specific Brain Networks to Treat Specific Symptoms in Depression
NA · 1 location(s) · Massachusetts General Hospital · NCT05523817
Metabolic Profiling of Esketamine Treatment in Depressive Disorder
Phase N/A · 1 location(s) · University of Zagreb · NCT07002684
Diagnostic Accuracy of the Stepped Screening Protocol and Its Screening Tools in the Perinatal Period.
Phase N/A · 2 location(s) · University Hospital, Ghent · NCT05961306
Brief Trial of ACT-i for Adults With Chronic Insomnia
NA · 1 location(s) · Babes-Bolyai University · NCT07048600
A Study to Evaluate the Effectiveness of Valbenazine in Adult Participants With Tardive Dyskinesia (TD) Who Remain Sympt
Phase 4 · 22 location(s) · Neurocrine Biosciences · NCT07105111
Accelerated Intermittent Theta Burst in Treatment-Naive Adolescents
NA · 1 location(s) · University of Texas at Austin · NCT06523439
Gamma Oscillations as a Prognostic Marker for Ketamine Therapy in Treatment Resistant Depression
Phase 1 · 2 location(s) · Texas A&M University · NCT06480201
Establishing Mobile Transcranial Magnetic Stimulation
Phase 4 · 1 location(s) · Medical University of South Carolina · NCT06748209
Home-Based tDCS for Depression in BPD
NA · 1 location(s) · Ciusss de L'Est de l'Île de Montréal · NCT06972368
Chinese Longitudinal and Systematic Study of Bioplar Disorder
NA · 1 location(s) · First Affiliated Hospital of Zhejiang University · NCT05480150
Exercise Training for Managing Major Depressive Disorder in Multiple Sclerosis
NA · 1 location(s) · University of Illinois at Chicago · NCT05051618
Home-Based Transcranial Direct Current Stimulation In Major Depressive Disorder (HOME)
NA · 6 location(s) · King's College London · NCT07228468
RESISTance Exercise for Depression Trial
NA · 2 location(s) · University of Wisconsin, Madison · NCT06110897
Feasibility and Efficacy of rTMS in Depression in Patients With Autism Spectrum Disorder (ASD)
NA · 1 location(s) · Hospital Center Guillaume Régnier · NCT07258914
No Time to Wait: Single Session Intervention
NA · 1 location(s) · United Christian Hospital · NCT07383467
E-field Guided iTBS for Treatment Resistant Depression
NA · 2 location(s) · Centre for Addiction and Mental Health · NCT05583747
Treating Loneliness In The Older Adult With Depression With tDCS
NA · 1 location(s) · Guangzhou Psychiatric Hospital · NCT06658795
Intravenous Ketamine for Treatment-Resistant Depression
Phase 2 · 1 location(s) · Mayo Clinic · NCT06668571
Brain Changes During Social Reward Psychotherapy for Mid- and Late-Life Suicidality
NA · 1 location(s) · Weill Medical College of Cornell University · NCT05925322
Improving Outcomes in Adolescent Inpatient Depression With Deep Transcranial Magnetic Stimulation
NA · 1 location(s) · Children's Hospital Medical Center, Cincinnati · NCT07217444
Electroconvulsive Therapy Augmented With Transcranial Magnetic Stimulation for Treatment Resistant Depression
NA · 1 location(s) · Charles University, Czech Republic · NCT07324070
Neural Circuit Effects of Ketamine in Depression
Phase 4 · 1 location(s) · Icahn School of Medicine at Mount Sinai · NCT06213324
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