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Study identifier: NCT07228468 Synced from ClinicalTrials.gov · August 07, 2026
● Study status: Recruiting

Home-Based Transcranial Direct Current Stimulation In Major Depressive Disorder (HOME)

Condition: Major Depressive Disorder (MDD)  ·  Sponsor: King's College London

PhaseNA
Planned participants438
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

Sponsor, CRO or site team? See where this study is running → — listed sites, countries and recruiting context. Everything below is written for patients and caregivers.

About this study

Depression is a prevalent and debilitating disorder. The most common treatments are antidepressant medications and talking therapies. However, for many individuals, these are not their treatment of choice. Furthermore, even following a full course of treatment with an antidepressant or talking therapy, over one third of patients continue to be unwell. The novel brain stimulation treatment, transcranial direct current stimulation (tDCS), is a potential first-line treatment for major depression. The present research question is whether home-based tDCS is an effective treatment for major depression for adults with major depression. Participants will be randomised to receive either a 10-week course of active tDCS treatment in addition to their standard care (Treatment as Usual), or to only receive Treatment as Usual. Participants will be followed up for 6-months after the start of the treatment began. After the 6-month follow-up visit, all participants from both groups can choose to continue/start the tDCS treatment. There will be a final follow-up visit 3 months later (9 months from the original treatment start of the trial).

This description comes directly from the study's public registry record.

Talk to the study team

Cynthia Fu  ·  020 7848 0002  ·  cynthia.fu@kcl.ac.uk

Always discuss trial participation with your own doctor first.

Locations (6)

Cardiff and Vale Health BoardCardiff, United KingdomNot Yet Recruiting
South London and Maudsley NHS Foundation TrustLondon, United KingdomRecruiting
Cumbria, Northumberland, Tyne and Wear NHS Foundation TrustNewcastle, United KingdomNot Yet Recruiting
Northamptonshire Healthcare NHS Foundation TrustNorthampton, United KingdomNot Yet Recruiting
Nottinghamshire Healthcare NHS Foundation TrustNottingham, United KingdomNot Yet Recruiting
Hampshire and Isle of Wight Healthcare NHS Foundation TrustSouthampton, United KingdomNot Yet Recruiting

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