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Condition: Treatment Resistant Major Depressive Disorder Synced from ClinicalTrials.gov · July 28, 2026

Recruiting studies: Treatment Resistant Major Depressive Disorder

Studies currently listed as recruiting on the public registry for this search term. Each page explains the study in plain language, with locations and the study team's contact details. Clinicians: generate a printable list for your patient →

Intravenous Ketamine for Treatment-Resistant Depression
Phase 2 · 1 location(s) · Mayo Clinic · NCT0666857140 Hz Light Neurostimulation for Patients With Depression (FELIX)
NA · 1 location(s) · Klaus Martiny · NCT05680220Maintenance rTMS for Depression (Maitr-De)
NA · 3 location(s) · University of California, San Diego · NCT06938841Comorbid Obesity and Depression With an Anti-inflammatory Medication
NA · 1 location(s) · King's College London · NCT06537921NMDA Receptor Antagonist Nitrous Oxide Targets Affective Brain Circuits
Phase 1 · 1 location(s) · Washington University School of Medicine · NCT02994433Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)
NA · 24 location(s) · Abbott Medical Devices · NCT06423430rTMS to Target Neural Connectivity and Rumination in Treatment-Resistant Depression
NA · 1 location(s) · Indiana University · NCT06511544Comparing the Efficacy of Accelerated vs. Standard fMRI-guided iTBS in Treating Adolescents Depression
NA · 1 location(s) · The Royal Ottawa Mental Health Centre · NCT06528938Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resi
Phase 2 · 1 location(s) · National Institute of Mental Health (NIMH) · NCT06511908Closed-Loop Deep Brain Stimulation for Major Depression
NA · 1 location(s) · Andrew Krystal · NCT04004169Accelerated iTBS for Major Depression
NA · 1 location(s) · Istanbul University - Cerrahpasa · NCT07603804Ketamine Alcohol (in Treatment-Resistant Depression)
Phase 2 · 1 location(s) · Mark Niciu · NCT02122562Comparison of the Efficacy of Accelerated Intermittent Theta Burst Stimulation and Accelerated Continuous Theta Burst St
NA · 1 location(s) · Ataturk University · NCT07264452Personalized Ultrasonic Brain Stimulation for Depression (R61)
Phase 1/Phase 2 · 1 location(s) · Brian Mickey · NCT06902298Accelerated vs. Conventional Theta Burst Stimulation for Late-life Depression
NA · 2 location(s) · Centre for Addiction and Mental Health · NCT06854367Ketamine Augmentation of ECT in Treatment-Resistant Depression
Phase 3 · 1 location(s) · Università Vita-Salute San Raffaele · NCT07088380i-CBT and IV Ketamine for Suicidality in Treatment-Resistant Depression: A Randomized, Midazolam-Controlled Clinical Tri
Phase 2 · 1 location(s) · University Health Network, Toronto · NCT06480500qEEG Brain Signature of Depression & Neuromodulation-induced Recovery
Phase 1 · 2 location(s) · Sunnybrook Health Sciences Centre · NCT06719427Digital Interventions for Adults with Treatment-Resistant Depression: a Pilot Study
Phase N/A · 1 location(s) · Unity Health Toronto · NCT06732089Closed-Loop Deep Brain Stimulation for Treatment-Resistant Bipolar Depression
NA · 1 location(s) · Andrew Krystal · NCT07127913Molecular Signatures of TMS Response in Treatment-Resistant Depression
NA · 2 location(s) · Gulhane Training and Research Hospital · NCT07039370Mindfulness Engaged Neurostimulation for Depression (MEND II)
Phase 2 · 1 location(s) · University of California, San Diego · NCT07512284The Effect of a Six Week Intensified Pharmacological Treatment for Major Depressive Disorder Compared to Treatment as Us
Phase 3 · 12 location(s) · Dr. Inge Winter · NCT05973851DBS for TRD With the Medtronic Percept PC
NA · 1 location(s) · Helen Mayberg, MD · NCT05773755Feasibility Trial of Exercise as a Priming Strategy for rTMS Treatment in Difficult-to-Treat Depression
NA · 1 location(s) · The Royal Ottawa Mental Health Centre · NCT06773949Physical Activity Program for TRD
NA · 1 location(s) · Unity Health Toronto · NCT06404320E-field Guided iTBS for Treatment Resistant Depression
NA · 2 location(s) · Centre for Addiction and Mental Health · NCT05583747Gamma Oscillations as a Prognostic Marker for Ketamine Therapy in Treatment Resistant Depression
Phase 1 · 2 location(s) · Texas A&M University · NCT06480201The Impact of Working Memory and Reward Markers on DLPFC Activity in Treatment-resistant Depression
NA · 1 location(s) · Unity Health Toronto · NCT06163625COpenhagen Magnetic Personalized Accelerated Brain Circuit Therapy for Treatment Resistant Depression
NA · 3 location(s) · Danish Research Centre for Magnetic Resonance · NCT06895863
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This page is independently generated by Eichor from the public ClinicalTrials.gov record and re-synced daily. It is not the sponsor's official website unless claimed. Nothing here is medical advice; eligibility is always determined by the study team — talk to your own doctor first.