Condition: Major Depressive Disorder (MDD) · Treatment Resistant Depression (TRD) · Sponsor: Istanbul University - Cerrahpasa
Major depressive disorder (MDD) is a common and disabling psychiatric condition, and many patients do not achieve adequate response to standard antidepressant treatments. Accelerated intermittent theta burst stimulation (iTBS) is a promising neuromodulation approach that may provide rapid antidepressant effects. This prospective interventional study aims to evaluate the clinical effectiveness of accelerated bilateral dorsomedial prefrontal cortex iTBS in patients with MDD and to investigate treatment-related changes in neurobiological biomarkers, including cortisol, ACTH, BDNF, IL-1β, IL-6, TNF-α, and CRP. Associations between biomarker changes and treatment response will also be examined.
This description comes directly from the study's public registry record.
Merve Rana Altunel Ülkü, MD · +90 506 303 10 68 · ranaltunel@gmail.com
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| Istanbul University - Cerrahpasa | Istanbul, Turkey (Türkiye) | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07603804