Condition: Treatment Resistant Depression · Sponsor: Danish Research Centre for Magnetic Resonance
The CoMPACT trial is a randomized double-blinded sham-controlled study aimed at testing a novel accelerated and personalized transcranial Magnetic Stimulation (TMS) treatment for patients with Treatment Resistant Depression (TRD). CoMPACT consists of 25 sessions of intermittent theta-burst transcranial stimulation (iTBS) consisting of high inter-pulse frequency administered five times daily over five consecutive days. The trial will include 78 patients with TRD who will be randomly assigned to one of three groups: * Group 1: Real CoMPACT targeting the left dorsolateral prefrontal cortex (DLPFC). * Group 2: Real CoMPACT targeting a novel site, the left inferior parietal lobule (IPL). * Group 3: Sham CoMPACT targeting the left DLPFC (50%, Group 3a) or left IPL (50%, Group 3b). The hypothesis is that real prefrontal or parietal CoMPACT targeting will significantly alleviate depression symptoms compared to sham targeting, without compromising safety, feasibility, or tolerability. The trial incorporates a personalized approach, using electrical field (E-field) modeling based on individual structural brain scans to tailor and standardize iTBS, ensuring accurate targeting of cortical volume and consistent induced electrical field strength. To delineate the treatment mechanism of action at the brain network level, multi brain mapping models will be implemented. Electroencephalography (EEG) records of spontaneous and TMS-evoked electrical brain activity will be obtained before, d…
This description comes directly from the study's public registry record.
Poul Videbech, Professor · +4538640634 · poul.videbech@regionh.dk
Iman Ibrahim, MD · +4591175914 · IIBR0007@regionh.dk
Always discuss trial participation with your own doctor first.
| Centre of Neuropsychiatric Depression Research | Glostrup Municipality, Denmark | Recruiting |
| Mental Health Center North Zealand | Hilleroed, Denmark | Not Yet Recruiting |
| Danish Research Centre for Magnetic Resonance | Hvidovre, Denmark | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT06895863