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Condition: Treatment Resistant Depression Synced from ClinicalTrials.gov · July 29, 2026

Recruiting studies: Treatment Resistant Depression

Studies currently listed as recruiting on the public registry for this search term. Each page explains the study in plain language, with locations and the study team's contact details. Clinicians: generate a printable list for your patient →

Cortical Inhibition as a Biomarker of Response in a Comparison of Bilateral Versus Unilateral Accelerated Theta Burst St
NA · 1 location(s) · University of California, San Diego · NCT05377177Deep Phenotyping for Clinical Inferring Response in Treatment Resistant Depression
Phase N/A · 1 location(s) · Max-Planck-Institute of Psychiatry · NCT06396312Spaced Transcranial Direct Current Stimulation for Treatment-Resistant Depression: A Home-Based Feasibility and Safety S
NA · 1 location(s) · University of California, San Diego · NCT07217223Magnetic Resonance-Guided Focused Ultrasound Bilateral Capsulotomy for the Treatment of Refractory Bipolar Depression
NA · 1 location(s) · Sunnybrook Health Sciences Centre · NCT07108257A Study of Esketamine Nasal Spray in Korean Participants With Treatment-resistant Depression
Phase 4 · 6 location(s) · Janssen Korea, Ltd., Korea · NCT07053345PCS in Severe Treatment Resistant Depression
NA · 1 location(s) · University of Minnesota · NCT04124341A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Thera
NA · 101 location(s) · LivaNova · NCT03887715Characterizing Dopamine Receptor Binding in Treatment Resistant Depression
Phase N/A · 1 location(s) · Unity Health Toronto · NCT03537794Deep Brain Stimulation of Treatment-Resistant Bipolar Depression
NA · 4 location(s) · Wayne Goodman MD · NCT06599099E-field Guided iTBS for Treatment Resistant Depression
NA · 2 location(s) · Centre for Addiction and Mental Health · NCT05583747Esketamine With or Without Integration Therapy for Treatment-Resistant Depression
Phase 4 · 2 location(s) · University of Puerto Rico · NCT07369102The Mechanisms of Underlying Accelerated Repetitive Transcranial Magnetic Stimulation for Treatment-resistant Depression
NA · 1 location(s) · First Affiliated Hospital of Zhejiang University · NCT05607654Accelerated TMS for Treatment-Resistant ECT
NA · 1 location(s) · Universitair Ziekenhuis Brussel · NCT07115628Belief Updating in Treatment Resistant Depression
Phase N/A · 1 location(s) · Assistance Publique - Hôpitaux de Paris · NCT05577247Evaluating the Role of Psilocybin Monitors in Psilocybin Therapy for Treatment Resistant Depression
Phase 2 · 2 location(s) · Centre for Addiction and Mental Health · NCT07211438Translational Biomarkers in Accelerated Neuromodulation for Treatment-resistant Depression
NA · 1 location(s) · ITAB - Institute for Advanced Biomedical Technologies · NCT05798143Esketamine Nasal Spray in Real-World Settings in Treatment-Resistant Depression
Phase N/A · 5 location(s) · Riccardo Guglielmo · NCT07146503Ketamine Augmentation of ECT in Treatment-Resistant Depression
Phase 3 · 1 location(s) · Università Vita-Salute San Raffaele · NCT07088380Molecular Signatures of TMS Response in Treatment-Resistant Depression
NA · 2 location(s) · Gulhane Training and Research Hospital · NCT07039370Medical Phenotyping of NHS General Adult Psychiatry (GAP) Inpatients
Phase N/A · 1 location(s) · University of Edinburgh · NCT07398365DBS for TRD With the Medtronic Percept PC
NA · 1 location(s) · Helen Mayberg, MD · NCT05773755Brexpiprazole Treatment for Bipolar I Depression
Phase 3 · 3 location(s) · Douglas Mental Health University Institute · NCT04569448Theta-Burst Stimulation for Bipolar Depression
NA · 2 location(s) · Centre for Addiction and Mental Health · NCT06370988Working Mechanisms and Effectiveness of IV Ketamine-assisted Psychotherapy on Depression in TRD Clients
Phase N/A · 1 location(s) · Senz · NCT07706478Intravenous Ketamine for Treatment-Resistant Depression
Phase 2 · 1 location(s) · Mayo Clinic · NCT06668571Mindfulness Engaged Neurostimulation for Depression (MEND II)
Phase 2 · 1 location(s) · University of California, San Diego · NCT07512284Effects of Transcranial Direct Current Stimulation (tDCS) in the Management of Suicidal Ideation
NA · 2 location(s) · Centre Hospitalier Henri Laborit · NCT06009523A Study to Assess the Efficacy, Safety and Tolerability of VLS-01 Buccal Film, Compared to Placebo in Patients With Trea
Phase 2 · 48 location(s) · atai Therapeutics, Inc. · NCT06524830Feasibility Trial of Exercise as a Priming Strategy for rTMS Treatment in Difficult-to-Treat Depression
NA · 1 location(s) · The Royal Ottawa Mental Health Centre · NCT0677394940 Hz Light Neurostimulation for Patients With Depression (FELIX)
NA · 1 location(s) · Klaus Martiny · NCT05680220
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This page is independently generated by Eichor from the public ClinicalTrials.gov record and re-synced daily. It is not the sponsor's official website unless claimed. Nothing here is medical advice; eligibility is always determined by the study team — talk to your own doctor first.