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Study identifier: NCT06719427 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

qEEG Brain Signature of Depression & Neuromodulation-induced Recovery

Condition: Major Depressive Diorder  ·  Sponsor: Sunnybrook Health Sciences Centre

PhasePhase 1
Planned participants100
Who can joinAll sexes, 18 Years to 80 Years
Healthy volunteersNo

About this study

This study aims to explore how repetitive transcranial magnetic stimulation (rTMS), a treatment for depression, affects brain function. Depression disrupts the brain's complex network or regions that regulate cognition, emotion, and behavior. rTMS targets these disruptions to restore network function. To measure these effects, researchers will use dry quantitative EEG (qEEG), a new technology that records brain electrical activity quickly (15 minutes compared to 1 hour for traditional EEG) without the need for gel or lengthy electrode setups. This study will evaluate a novel qEEG activity developed by iMediSync (Republic of South Korea) in patients treated with neuromodulation for depression before, during, and up to 12 months after treatment to see if changes in brain activity to identify patterns associated with symptomatic improvement and relapse risk. Findings could help personalize depression treatments by predicting patient outcomes and optimizing care.

This description comes directly from the study's public registry record.

Talk to the study team

Sean M Nestor, M.D.  ·  416-347-0257  ·  sean.nestor@utoronto.ca

Chris B Pople, MSc  ·  416-474-5512  ·  chris.pople@mail.utoronto.ca

Always discuss trial participation with your own doctor first.

Locations (2)

Sunnybrook Health Sciences CentreNorth York, Ontario, CanadaNot Yet Recruiting
Sunnybrook Health Sciences CentreToronto, Ontario, CanadaRecruiting

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Source record: clinicaltrials.gov/study/NCT06719427