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Study identifier: NCT06423430 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)

Condition: Treatment Resistant Depression  ·  Sponsor: Abbott Medical Devices

PhaseNA
Planned participants100
Who can joinAll sexes, 22 Years to 70 Years
Healthy volunteersNo

About this study

The goal of this clinical trial is to evaluate the effectiveness and safety of bilateral stimulation of the subcallosal cingulate white matter (SCCwm) using Deep Brain Stimulation (DBS) as an adjunctive treatment of non-psychotic unipolar Major Depressive Disorder (MDD) in adults.

This description comes directly from the study's public registry record.

Talk to the study team

Natalie Danovsky  ·  +16517563842  ·  natalie.richardson@abbott.com

Lyndahl Himes  ·  lyndahl.himes@abbott.com

Always discuss trial participation with your own doctor first.

Locations (24)

University of Alabama at Birmingham - Dept. of PsychiatryBirmingham, Alabama, United StatesRecruiting
USC University HospitalLos Angeles, California, United StatesRecruiting
UCLA Department of PsychiatryLos Angeles, California, United StatesRecruiting
University of California at DavisSacramento, California, United StatesRecruiting
USF HealthTampa, Florida, United StatesRecruiting
Emory University HospitalAtlanta, Georgia, United StatesRecruiting
Rush University Medical CenterChicago, Illinois, United StatesRecruiting
Indiana UniversityIndianapolis, Indiana, United StatesRecruiting
Massachusetts General HospitalBoston, Massachusetts, United StatesRecruiting
Beth Israel Deaconess Medical CenterBoston, Massachusetts, United StatesRecruiting
University of Minnesota Medical Center FairviewMinneapolis, Minnesota, United StatesRecruiting
Mayo ClinicRochester, Minnesota, United StatesRecruiting

+ 12 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06423430