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Condition: Diffuse Midline Glioma Synced from ClinicalTrials.gov · July 28, 2026

Recruiting studies: Diffuse Midline Glioma

Studies currently listed as recruiting on the public registry for this search term. Each page explains the study in plain language, with locations and the study team's contact details. Clinicians: generate a printable list for your patient →

A Study of 177Lu-PSMA-617 in People With Gliomas
Phase 1 · 7 location(s) · Memorial Sloan Kettering Cancer Center · NCT07223034Combination Therapy for the Treatment of Diffuse Midline Gliomas
Phase 2 · 32 location(s) · University of California, San Francisco · NCT05009992FUS Etoposide for DMG
Phase 1 · 1 location(s) · Columbia University · NCT05762419Atovaquone Combined With Radiation in Children With Malignant Brain Tumors
Phase 1 · 2 location(s) · Emory University · NCT06624371Testing the Addition of an Anti-Cancer Drug, AZD1390, During Radiation Therapy for Newly Diagnosed High Grade Glioma, Di
Phase 1 · 20 location(s) · Children's Oncology Group · NCT06894979Study of Olutasidenib and Temozolomide in HGG
Phase 2 · 20 location(s) · Rigel Pharmaceuticals · NCT06161974ONC206 for Treatment of Newly Diagnosed, Recurrent Diffuse Midline Gliomas, and Other Recurrent Malignant CNS Tumors
Phase 1 · 7 location(s) · Sabine Mueller, MD, PhD · NCT04732065Testing the Addition of an Anti-Cancer Drug, Triapine, to the Usual Radiation Therapy for Recurrent Glioblastoma or Astr
Phase 1 · 43 location(s) · National Cancer Institute (NCI) · NCT06860594Biological Medicine for Diffuse Intrinsic Pontine Glioma (DIPG) Eradication 2.0
Phase 3 · 50 location(s) · Gustave Roussy, Cancer Campus, Grand Paris · NCT05476939Stereotactic Biopsy Split-Course Radiation Therapy in Diffuse Midline Glioma, SPORT-DMG Trial
Phase 2 · 2 location(s) · Mayo Clinic · NCT05077735rHSC-DIPGVax Plus Checkpoint Blockade for the Treatment of Newly Diagnosed DIPG and DMG
Phase 1 · 3 location(s) · Ann & Robert H Lurie Children's Hospital of Chicago · NCT04943848Targeted Pediatric High-Grade Glioma Therapy
Phase N/A · 21 location(s) · Nationwide Children's Hospital · NCT05839379H3K27M-specific Immune Effector Cells Targeting DMG/DIPG
Phase 1/Phase 2 · 1 location(s) · Shenzhen Geno-Immune Medical Institute · NCT07501156CD200AR-L and Allogeneic Tumor Lysate Vaccine Immunotherapy for Recurrent HGG and Newly Diagnosed DMG/DIPG in Children a
Phase 1 · 1 location(s) · OX2 Therapeutics · NCT06305910xPedite: A Study to Expedite DIPG and DMG Research
Phase N/A · 1 location(s) · xCures · NCT06140719ONC201 in H3 K27M-mutant Diffuse Glioma Following Radiotherapy (the ACTION Study)
Phase 3 · 162 location(s) · Jazz Pharmaceuticals · NCT05580562Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Gliom
Phase 1 · 1 location(s) · Seattle Children's Hospital · NCT04185038GD2-CAR T Cells for Pediatric Brain Tumours
Phase 1 · 1 location(s) · Bambino Gesù Hospital and Research Institute · NCT05298995CAR T Cells to Target GD2 for DMG
Phase 1 · 1 location(s) · University College, London · NCT05544526Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant
Phase 2 · 20 location(s) · Nationwide Children's Hospital · NCT05843253Multicenter Prospective Study on MRI AI Model for Midline Glioma Subtyping and Prognosis:
Phase N/A · 1 location(s) · Xiangya Hospital of Central South University · NCT07608003Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms
Phase 1 · 1 location(s) · Jazz Pharmaceuticals · NCT04541082CBL0137 for the Treatment of Relapsed or Refractory Solid Tumors, Including CNS Tumors and Lymphoma
Phase 1/Phase 2 · 35 location(s) · Children's Oncology Group · NCT04870944GD2 CAR T Cells in Diffuse Intrinsic Pontine Gliomas (DIPG) & Spinal Diffuse Midline Glioma(DMG)
Phase 1 · 1 location(s) · Stanford University · NCT04196413Observational Study for Assessing Treatment and Outcome of Patients With Primary Brain Tumours Using cIMPACT-NOW and 202
Phase N/A · 42 location(s) · European Organisation for Research and Treatment of Cancer - · NCT05259605MCT for the Harvard/UCSF ROBIN Center
NA · 2 location(s) · Brigham and Women's Hospital · NCT06000787International Diffuse Intrinsic Pontine Glioma (DIPG)/Diffuse Midline Glioma (DMG) Registry and Repository
Phase N/A · 1 location(s) · Children's Hospital Medical Center, Cincinnati · NCT03101813A Study of VRT106 in Combination With Radiotherapy in Adult Patients With Diffuse Midline Glioma / Diffuse Intrinsic Pon
Phase 2 · 1 location(s) · Guangzhou Virotech Pharmaceutical Co., Ltd. · NCT07589257Engineered HSV-1 M032 for the Treatment of Children and Adults With Newly Diagnosed Diffuse Midline Glioma After Standar
Phase 1 · 1 location(s) · M.D. Anderson Cancer Center · NCT07076498Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion
EARLY_Phase 1 · 18 location(s) · Nationwide Children's Hospital · NCT06333899
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This page is independently generated by Eichor from the public ClinicalTrials.gov record and re-synced daily. It is not the sponsor's official website unless claimed. Nothing here is medical advice; eligibility is always determined by the study team — talk to your own doctor first.