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Study identifier: NCT05544526 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

CAR T Cells to Target GD2 for DMG

Condition: Diffuse Midline Glioma, H3 K27M-Mutant  ·  Sponsor: University College, London

PhasePhase 1
Planned participants12
Who can joinAll sexes, N/A to 16 Years
Healthy volunteersNo

About this study

The CARMIGO Trial is a single-centre, non-randomised, open label Phase I clinical trial of an Advanced Therapy Investigational Medicinal Product (ATIMP) in children and young adults aged 2-16 years with Diffuse Midline Glioma (DMG). The study will evaluate the feasibility of generating the ATIMP, the safety and tolerability of the GD2CAR T-cell therapy and how effectively GD2CAR T-cells engraft, expand and persist following administration in patients with DMG.

This description comes directly from the study's public registry record.

Talk to the study team

CARMIGO Trial Coordinator  ·  0207 679 9599  ·  ctc.CARMIGO@ucl.ac.uk

Karin Straathof

Always discuss trial participation with your own doctor first.

Locations (1)

Great Ormond Street HospitalLondon, United KingdomRecruiting

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Source record: clinicaltrials.gov/study/NCT05544526