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Study identifier: NCT04541082 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms

Condition: Central Nervous System Neoplasms · Glioblastoma · Gliosarcoma, Adult  ·  Sponsor: Jazz Pharmaceuticals

PhasePhase 1
Planned participants102
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The primary objective of this Phase 1, open-label, dose-escalation, and exploratory study is to evaluate the safety and tolerability profile (establish the maximum-tolerated dose) and evaluate the occurrence of dose-limiting toxicities (DLTs) following single weekly or multiple-day weekly dose regimens of single-agent, oral ONC206 in patients with recurrent, primary central nervous system (CNS) neoplasms.

This description comes directly from the study's public registry record.

Talk to the study team

Clinical Trial Disclosure & Transparency  ·  215-832-3750  ·  ClinicalTrialDisclosure@jazzpharma.com

Always discuss trial participation with your own doctor first.

Locations (1)

National Institutes of HealthBethesda, Maryland, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT04541082