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Study identifier: NCT06624371 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Atovaquone Combined With Radiation in Children With Malignant Brain Tumors

Condition: High-grade Glioma · Medulloblastoma · Diffuse Intrinsic Pontine Glioma  ·  Sponsor: Emory University

PhasePhase 1
Planned participants18
Who can joinAll sexes, 2 Years to 25 Years
Healthy volunteersNo

About this study

The goal of this interventional study is to Assess the safety and tolerability of atovaquone in combination with standard radiation therapy (RT) for the treatment of pediatric patients with newly diagnosed pediatric high-grade glioma/diffuse midline glioma/diffuse intrinsic pontine glioma (pHGG/DMG/DIPG). The secondary aim is to assess the safety and tolerability of longer-term atovaquone treatment for pediatric patients with relapsed or progressed pHGG/DMG/DIPG and medulloblastoma (MB) or pHGG/DMG/DIPG after completion of RT and before progression.

This description comes directly from the study's public registry record.

Talk to the study team

Tobey MacDonald, MD  ·  404-727-1447  ·  aflacdevtreferral@choa.org

Amber Kaminski  ·  aflacdevtreferral@choa.org

Always discuss trial participation with your own doctor first.

Locations (2)

Arthur M Blank HospitalAtlanta, Georgia, United StatesRecruiting
Children's Healthcare of Atlanta: Scottish RiteAtlanta, Georgia, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06624371