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Condition: Leptomeningeal Metastasis Synced from ClinicalTrials.gov · July 28, 2026

Recruiting studies: Leptomeningeal Metastasis

Studies currently listed as recruiting on the public registry for this search term. Each page explains the study in plain language, with locations and the study team's contact details. Clinicians: generate a printable list for your patient →

Stupp Treatment With Intrathecal Injection of Thiotepa for Glioblastoma With Advanced Spread
Phase 2 · 1 location(s) · Second Affiliated Hospital, School of Medicine, Zhejiang Uni · NCT07193654Multiple Dose Intraventricular Administration of Rhenium-186 NanoLiposome for Leptomeningeal Metastases
Phase 1 · 1 location(s) · Plus Therapeutics · NCT07098806Efficacy and Resistance Mechanisms of IP in NSCLC With Leptomeningeal Metastases
Phase 2 · 1 location(s) · Hunan Province Tumor Hospital · NCT06440954Intrathecal Injection Pemetrexed And Bevacizumab in Patients With Leptomeningeal Metastases in NSCLC
Phase 1 · 1 location(s) · Shanghai Chest Hospital · NCT06663306Sacituzumab Govitecan and Intrathecal Chemotherapy for Treating Leptomeningeal Metastases From Her2-negative Breast Canc
Phase 1/Phase 2 · 1 location(s) · Guangzhou Medical University · NCT06462092Efficacy and Safety of Intrathecal Administration of Thiotepa in Combination With Methotrexate in Breast Cancer With Lep
Phase 2 · 1 location(s) · The First Affiliated Hospital with Nanjing Medical Universit · NCT06543992CSF Analysis in EGFR Mutant Non-Small Cell Lung Cancer With Leptomeningeal Disease
NA · 1 location(s) · British Columbia Cancer Agency · NCT05257967Pulsatile High-dose Furmonertinib in EGFR-mutant NSCLC With Leptomeningeal Metastasis
NA · 1 location(s) · Guangzhou University of Traditional Chinese Medicine · NCT07348965A Study of the Safety and Efficacy of Pemetrexed Combined with Nivolumab Via Intraventricular Injection for the Treatmen
Phase 2 · 1 location(s) · Shanghai Cancer Hospital, China · NCT06901817Firmonertinib Combined With Intrathecal Injection for the Treatment of EGFR Mutant NSCLC With Leptomeningeal Metastases
Phase 4 · 1 location(s) · Union Hospital, Tongji Medical College, Huazhong University · NCT07092202Efficacy and Safety of Intraventricule Pemetrexed Disodium Administered Via Ommaya Reservoir
Phase N/A · 1 location(s) · Xiangya Hospital of Central South University · NCT06399926Standardized Clinical Assessment of Patients With Leptomeningeal Metastasis
Phase N/A · 3 location(s) · University of Zurich · NCT06417710Zorifertinib With Osimertinib for NSCLC With Meningeal Progression
Phase 1 · 5 location(s) · Alpha Biopharma (Jiangsu) Co., Ltd. · NCT07361705Patient Perceptions Around Quality of Care Through Telemedicine in Neuro-Oncology
Phase N/A · 1 location(s) · M.D. Anderson Cancer Center · NCT04988009Photon Craniospinal Irradiation for the Treatment of Leptomeningeal Disease Secondary to Breast Cancer or Non-small Cell
Phase 2 · 2 location(s) · City of Hope Medical Center · NCT06910761Safety and Efficacy of Whole Brain LDRT+ICI+Intrathecal Chemotherapy in Refractory Meningeal Metastasis of Lung Cancer
Phase 1 · 1 location(s) · Sichuan University · NCT06431685Intrathecal Chemotherapy Through Ommaya Reservoir Upon Her-2 Negative Breast Cancer With Leptomeningeal Metastasis
Phase 4 · 1 location(s) · Fudan University · NCT06230055Testing Proton Craniospinal Radiation Therapy Versus the Usual Radiation Therapy for Leptomeningeal Metastasis, RADIATE-
Phase 3 · 58 location(s) · NRG Oncology · NCT06500481Evaluating High-dose Furmonertinib with Bevacizumab and Pemetrexed for EGFRm NSCLC with Leptomeningeal Metastasis
NA · 2 location(s) · Henan Cancer Hospital · NCT06643000Intrathecal Application of PD1 Antibody in Metastatic Solid Tumors With Leptomeningeal Disease (IT-PD1/ NOA 26)
Phase 1 · 9 location(s) · University Hospital Tuebingen · NCT05112549Double-Dose Third-Generation EGFR-TKI Plus Bevacizumab and Intrathecal Chemotherapy for Refractory Leptomeningeal Metast
NA · 1 location(s) · Second Affiliated Hospital of Nanchang University · NCT07398599A Study of Deferoxamine (DFO) in People With Leptomeningeal Metastasis
Phase 1 · 7 location(s) · Memorial Sloan Kettering Cancer Center · NCT05184816A Real-world Study on the Treatment of Non-small Cell Lung Cancer With Leptomeningeal Metastasis in China
Phase N/A · 2 location(s) · Guangzhou Medical University · NCT06718972Exploration of the Application of Methotrexate-loaded Drug Vesicles in Intrathecal Injection for Meningeal Metastasis of
Phase 1/Phase 2 · 1 location(s) · Henan Cancer Hospital · NCT07559097Tucatinib, Trastuzumab and Capecitabine With Brain and/or Spinal Radiotherapy (XRT) in Patients With HER2+, HER2 Mutated
Phase 2 · 2 location(s) · Sunnybrook Health Sciences Centre · NCT06016387Tumor Treating Fields for the Treatment of Leptomeningeal Metastases of the Spine in Patients With Breast or Lung Cancer
NA · 1 location(s) · Mayo Clinic · NCT05746325Prospective Evaluation Of High-Dose Systemic Methotrexate In Patients With Breast Cancer And Leptomeningeal Metastasis
Phase 2 · 3 location(s) · Wake Forest University Health Sciences · NCT02422641Hippocampal Avoidance in Craniospinal Irradiation for the Treatment of Leptomeningeal Metastases From Breast Cancer or N
Phase 2 · 2 location(s) · University of Washington · NCT06518057Immune Checkpoint Inhibitors Intrathecal Injection in Patients With Leptomeningeal Metastases in NSCLC
Phase 2 · 1 location(s) · West China Hospital · NCT06132698Capecitabine, Tucatinib, and Intrathecal Trastuzumab for Breast Cancer Patients With Leptomeningeal Disease
Phase 2 · 11 location(s) · UNICANCER · NCT05800275
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This page is independently generated by Eichor from the public ClinicalTrials.gov record and re-synced daily. It is not the sponsor's official website unless claimed. Nothing here is medical advice; eligibility is always determined by the study team — talk to your own doctor first.