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Study identifier: NCT02422641 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Prospective Evaluation Of High-Dose Systemic Methotrexate In Patients With Breast Cancer And Leptomeningeal Metastasis

Condition: Metastatic Breast Cancer · Leptomeningeal Disease  ·  Sponsor: Wake Forest University Health Sciences

PhasePhase 2
Planned participants16
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This study is a prospective evaluation of systemic, intravenous high-dose methotrexate (HD-MTX, 8 g/m2) in patients with triple negative, HER2-positive, and hormone refractory breast cancer with leptomeningeal metastasis (LMD) with or without brain parenchymal involvement.

This description comes directly from the study's public registry record.

Talk to the study team

Sara Cox  ·  336-713-7748  ·  Sara.Cox@advocatehealth.org

Strowd Roy, MD  ·  rstrowd@wakehealth.edu

Always discuss trial participation with your own doctor first.

Locations (3)

Sidney Kimmel Comprehensive Cancer CenterBaltimore, Maryland, United StatesRecruiting
Siteman Cancer Center- Washington University School of Medicine in St. LouisSt Louis, Missouri, United StatesActive Not Recruiting
Comprehensive Cancer Center at Wake Forest University (CCCWFU)Winston-Salem, North Carolina, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT02422641