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Study identifier: NCT07361705 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Zorifertinib With Osimertinib for NSCLC With Meningeal Progression

Condition: Patients With Advanced Non-small Cell Lung Cancer With Meningeal Progression After Osimertinib Treatment  ·  Sponsor: Alpha Biopharma (Jiangsu) Co., Ltd.

PhasePhase 1
Planned participants42
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is a clinical trial that aims to test Zorifertinib when used together with a known drug, Osimertinib. The goal is to learn if this combination is safe and works for people with advanced Non-Small Cell Lung Cancer (NSCLC) whose cancer has spread to the membranes surrounding the brain and spinal cord (a condition called leptomeningeal metastases) after being treated with Osimertinib.

This description comes directly from the study's public registry record.

Talk to the study team

John Ge, M.D  ·  +86 (0)21-63862197  ·  john.ge@alphabiopharma.com.cn

Always discuss trial participation with your own doctor first.

Locations (5)

Cancer Hospital Chinese Academy of Medical SciencesBeijing, Beijing Municipality, ChinaRecruiting
The First Affiliated Hospital of China Medical UniversityShengyang, City, ChinaRecruiting
Chinese Academy of Medical Sciences Cancer Hospital Shenzhen HospitalGuangzhou, Province, ChinaRecruiting
Henan Cancer HospitalHenan, Province, ChinaRecruiting
Shanxi Cancer HospitalShanxi, Province, ChinaRecruiting

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Source record: clinicaltrials.gov/study/NCT07361705