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Study identifier: NCT06399926 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Efficacy and Safety of Intraventricule Pemetrexed Disodium Administered Via Ommaya Reservoir

Condition: Leptomeningeal Metastasis · Lung Cancer  ·  Sponsor: Xiangya Hospital of Central South University

PhaseN/A
Planned participants64
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is a open-label, multi-center prospective observation study for the efficacy and safety of intraventricle pemetrexed disodium via ommaya reservoir in the treatment of leptomeningeal metastasis with lung cancer who have failed at least one targeted therapy. In detail: At least the treatment failure was after third-generation EGFR-TKIs in EGFR-mutated lung cancer; or at least the treatment failure was after second-generation ALK-TKIs in ALK-mutated lung cancer; or at least the treatment failure was after one-line of targeted-TKIs in ROS1-mutated non-squamous non-small lung cancer.

This description comes directly from the study's public registry record.

Talk to the study team

bin Li, doctor  ·  13467713587  ·  bincsuxy@csu.edu.cn

xiangping Li, pharmacist  ·  13873181829  ·  xylxping@126.com

Always discuss trial participation with your own doctor first.

Locations (1)

Xiangya Hospital Central South UniversityChangsha, Hunan, ChinaRecruiting

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Source record: clinicaltrials.gov/study/NCT06399926