Condition: Leptomeningeal Metastases · Sponsor: Guangzhou Medical University
Leptomeningeal metastases (LM) is a lethal complication of malignant tumors, characterized by tumor cell invasion and proliferation within the subarachnoid space. LM from HER2-negative breast cancer remains challenging to treat, with a median overall survival of only 3-6 months despite aggressive therapy. This open-label, uncontrolled Phase I/II clinical study aims to evaluate the safety, feasibility, and potential efficacy of Sacituzumab Govitecan in combination with intrathecal pemetrexed chemotherapy for LM from HER2-negative breast cancer, with the objective of identifying a more effective treatment strategy.
This description comes directly from the study's public registry record.
Zhenyu Pan · +8618718178286 · dr-zypan@163.com
Guozi Yang · +8615804302755 · guoziyang_1982@163.com
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| The Affiliated Huizhou Hospital, Guangzhou Medical University | Huizhou, Guangdong, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06462092