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Study identifier: NCT06016387 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Tucatinib, Trastuzumab and Capecitabine With Brain and/or Spinal Radiotherapy (XRT) in Patients With HER2+, HER2 Mutated and/or HER2-amplified Metastatic Breast Cancer and Leptomeningeal Disease: A Multi-centre Phase II, Single Arm Feasibility Study

Condition: HER2-positive Breast Cancer · LMD  ·  Sponsor: Sunnybrook Health Sciences Centre

PhasePhase 2
Planned participants30
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The proposed study will evaluate the safety and efficacy of XRT followed by systemic therapy among patients with HER2+, HER2 mutated and/or HER2-amplified metastatic breast cancer and LMD

This description comes directly from the study's public registry record.

Talk to the study team

CLIMB-LMD Project Manager  ·  437-247-2617  ·  CLIMB-LMD@sunnybrook.ca

Dr. Katarzyna Jerzak  ·  437-247-2617  ·  katarzyna.jerzak@sunnybrook.ca

Always discuss trial participation with your own doctor first.

Locations (2)

The Ottawa HospitalOttawa, Ontario, CanadaRecruiting
Sunnybrook Health Sciences CentreToronto, Ontario, CanadaRecruiting

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Source record: clinicaltrials.gov/study/NCT06016387