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Study identifier: NCT07388667 Synced from ClinicalTrials.gov · August 08, 2026
● Study status: Active Not Recruiting

A Clinical Study of MK-4082 in Healthy Overweight Participants (MK-4082-002)

Condition: Healthy  ·  Sponsor: Merck Sharp & Dohme LLC

PhasePhase 1
Planned participants120
Who can joinAll sexes, 18 Years to 60 Years
Healthy volunteersYesCheck eligibility criteria ↓
Where5 locations

Sponsor, CRO or site team? See where this study is running → — listed sites, countries and recruiting context. Everything below is written for patients and caregivers.

About this study

Researchers are looking for new weight loss medicines for people with higher body weight. The study medicine, MK-4082, is different from similar weight loss medicines because people take it as a pill instead of an injection. Before giving a study medicine to people with a health condition, researchers first do studies to find a safe dose level (amount) of the study medicine that can be used in future studies. The goals of this study are to learn about: * The safety of MK-4082 and if people tolerate it * What happens to different MK-4082 dose levels in a person's body over time

This description comes directly from the study's public registry record.

Talk to the study team

No contact information is available for this study as per the public registry record.

Always discuss trial participation with your own doctor first.

Full eligibility criteria (exactly as the study team wrote them)

Inclusion Criteria: The main inclusion criteria include but are not limited to the following: * Is in good health * Has body mass index (BMI) between 25 and 40 kg/m\^2, inclusive. Participants must weigh at least 60 kg Exclusion Criteria: The main exclusion criteria include but are not limited to the following: * has a history of previous surgical treatment for obesity (bariatric surgery, gastric banding, etc.) or any other gastrointestinal (GI) surgery that may induce malabsorption, history of bowel resection \>20 cm, any malabsorption disorder, severe gastroparesis, or any GI procedure for weight loss (including LAP-BAND®), as well as clinically significant GI disorders (eg, peptic ulcers, severe gastroesophageal reflux disease) * has an individual or family history of medullary thyroid carcinoma or multiple endocrine neoplasia 2

Reproduced word-for-word from the public registry record — the study team can answer questions about it.

Locations (5)

Anaheim Clinical Trials ( Site 0005)Anaheim, California, United States
ProSciento Inc. ( Site 0002)Chula Vista, California, United States
QPS-MRA, LLC ( Site 0003)South Miami, Florida, United States
Bio-Kinetic Clinical Applications, LLD dba QPS-MO ( Site 0004)Springfield, Missouri, United States
Hassman Research Institute Marlton Site ( Site 0006)Marlton, New Jersey, United States

More studies in these areas

This study lists sites in the areas below. Each link shows other recruiting studies near that city, from the public registry record.

AnaheimChula VistaSouth MiamiSpringfield

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