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Condition: Depressive Disorder Treatment Resistant Synced from ClinicalTrials.gov · July 28, 2026

Recruiting studies: Depressive Disorder Treatment Resistant

Studies currently listed as recruiting on the public registry for this search term. Each page explains the study in plain language, with locations and the study team's contact details. Clinicians: generate a printable list for your patient →

Intravenous Ketamine for Treatment-Resistant Depression
Phase 2 · 1 location(s) · Mayo Clinic · NCT06668571
Olfactory and Brain Stimulations in Treatment-resistant Depression
NA · 1 location(s) · Hôpital le Vinatier · NCT05661383
Low Frequency Right Dorsolateral Pre Frontal Cortical Repetitive TMS for Bipolar Depression
Phase 3 · 2 location(s) · Tyler Kaster · NCT06986460
Tractography Guided Subcallosal Cingulate Deep Brain Stimulation for Treatment Resistant Depression
NA · 1 location(s) · Nader Pouratian · NCT03952962
40 Hz Light Neurostimulation for Patients With Depression (FELIX)
NA · 1 location(s) · Klaus Martiny · NCT05680220
The Mechanisms of Underlying Accelerated Repetitive Transcranial Magnetic Stimulation for Treatment-resistant Depression
NA · 1 location(s) · First Affiliated Hospital of Zhejiang University · NCT05607654
Maintenance rTMS for Depression (Maitr-De)
NA · 3 location(s) · University of California, San Diego · NCT06938841
Adjunctive Allogeneic Mesenchymal Stem Cells for Treatment-resistant Bipolar Depression
Phase 1 · 1 location(s) · The University of Texas Health Science Center, Houston · NCT03522545
Comorbid Obesity and Depression With an Anti-inflammatory Medication
NA · 1 location(s) · King's College London · NCT06537921
Psilocybin for Hospitalized Patients with Treatment-resistant Depression
Phase 2 · 1 location(s) · University Hospital, Ghent · NCT06378229
Psilocybe Cubensis Mushrooms With or Without Fluoxetine for Refractory Depression
Phase 1/Phase 2 · 1 location(s) · Federal University of Latin American Integration · NCT06898606
NMDA Receptor Antagonist Nitrous Oxide Targets Affective Brain Circuits
Phase 1 · 1 location(s) · Washington University School of Medicine · NCT02994433
Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)
NA · 24 location(s) · Abbott Medical Devices · NCT06423430
rTMS to Target Neural Connectivity and Rumination in Treatment-Resistant Depression
NA · 1 location(s) · Indiana University · NCT06511544
Comparing the Efficacy of Accelerated vs. Standard fMRI-guided iTBS in Treating Adolescents Depression
NA · 1 location(s) · The Royal Ottawa Mental Health Centre · NCT06528938
Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resi
Phase 2 · 1 location(s) · National Institute of Mental Health (NIMH) · NCT06511908
DBS for Depression
Phase 1 · 1 location(s) · Northwell Health · NCT06096207
A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Thera
NA · 101 location(s) · LivaNova · NCT03887715
taVNS or TMS or Both for Depression
NA · 1 location(s) · Medical University of South Carolina · NCT05725239
Neurobiological Effects of Psilocybin in Treatment Resistant Bipolar Depression
Phase 1 · 1 location(s) · University Health Network, Toronto · NCT06506019
Brexpiprazole Treatment for Bipolar I Depression
Phase 3 · 3 location(s) · Douglas Mental Health University Institute · NCT04569448
Closed-Loop Deep Brain Stimulation for Major Depression
NA · 1 location(s) · Andrew Krystal · NCT04004169
OSU6162 as add-on in SSRI/SNRI-resistant Depression
Phase 2 · 4 location(s) · Göteborg University · NCT05641623
Magnetic Resonance-Guided Focused Ultrasound Bilateral Capsulotomy for the Treatment of Refractory Bipolar Depression
NA · 1 location(s) · Sunnybrook Health Sciences Centre · NCT07108257
Imaging the Effects of Serotonin 2A Receptor Modulation on Synaptic Density in Treatment-resistant Depression (SYNVEST)
Phase 2 · 1 location(s) · Centre for Addiction and Mental Health · NCT06512220
Effects of Transcranial Direct Current Stimulation (tDCS) in the Management of Suicidal Ideation
NA · 2 location(s) · Centre Hospitalier Henri Laborit · NCT06009523
Accelerated iTBS for Major Depression
NA · 1 location(s) · Istanbul University - Cerrahpasa · NCT07603804
Ketamine Alcohol (in Treatment-Resistant Depression)
Phase 2 · 1 location(s) · Mark Niciu · NCT02122562
Treatment With Psilocybin for Chronic Neuropathic Pain and Depression (TRANSCEND)
Phase 2 · 1 location(s) · Centre for Addiction and Mental Health · NCT06518720
Coaching as an Adjunct to Ketamine Therapy for Treatment-Resistant Depression
NA · 2 location(s) · Massachusetts General Hospital · NCT07563868
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This page is independently generated by Eichor from the public ClinicalTrials.gov record and re-synced daily. It is not the sponsor's official website unless claimed. Nothing here is medical advice; eligibility is always determined by the study team — talk to your own doctor first.