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Study identifier: NCT07563868 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Coaching as an Adjunct to Ketamine Therapy for Treatment-Resistant Depression

Condition: Treatment Resistant Depression (TRD)  ·  Sponsor: Massachusetts General Hospital

PhaseNA
Planned participants20
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This study is being conducted at Massachusetts General Hospital (MGH) to explore whether adding psychedelic coaching can enhance the effects of ketamine or esketamine maintenance treatment in individuals with treatment-resistant depression (TRD). The investigators are currently enrolling participants who are receiving ongoing maintenance intravenous (IV) ketamine or intranasal esketamine (Spravato) treatment at the MGH Ketamine Clinic. Participation in the study will involve adding coaching sessions to your existing ketamine maintenance treatment.

This description comes directly from the study's public registry record.

Talk to the study team

Maren Nyer, PhD  ·  6176434897  ·  mnyer@mgh.harvard.edu

Franklin King, MD  ·  fking@mgh.harvard.edu

Always discuss trial participation with your own doctor first.

Locations (2)

Massachusetts General Hospital's Depression and Clinical Research programBoston, Massachusetts, United StatesRecruiting
Massachusetts General HospitalBoston, Massachusetts, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT07563868