EICHORCondition: Brain Metastases From Solid Tumors · Leptomeningeal Disease · High Grade Glioma (HGG) · Sponsor: Jubilant Therapeutics Inc.
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This is a Phase 1/2, multicenter, open-label, dose-escalation and dose-expansion study evaluating the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), cerebrospinal fluid penetration, and preliminary antitumor activity of orally administered JBI-778, a selective PRMT5 inhibitor, in patients with brain metastases, leptomeningeal disease, or recurrent high-grade glioma. The study consists of a dose-escalation phase to determine the maximum tolerated dose (MTD) and recommended Phase 2 dose (RP2D), followed by expansion cohorts to evaluate preliminary efficacy at the RP2D.
This description comes directly from the study's public registry record.
Melda Dolan, MD · 3144989959 · Melda.Dolan@jubl.com
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Source record: clinicaltrials.gov/study/NCT07751744