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Study identifier: NCT07751380 Synced from ClinicalTrials.gov · August 07, 2026
● Study status: Recruiting

Multi-modular Chimeric Antigen Receptor T Cells tarGeting B7-H3 in Children, Teenage & Young Adult Sarcoma

Condition: Sarcoma  ·  Sponsor: University College, London

PhasePhase 1
Planned participants12
Who can joinAll sexes, 1 Year to 24 Years
Healthy volunteersNo

Sponsor, CRO or site team? See where this study is running → — listed sites, countries and recruiting context. Everything below is written for patients and caregivers.

About this study

MIGHTY is a multicentre, open label, phase 1 clinical trial of an Advanced Therapy Investigational Medicinal Product (ATIMP) in children, teenagers and young adults aged 1-24 with relapsed or refractory (r/r) rhabdomyosarcoma (RMS), Ewing sarcoma (ES) or desmoplastic small round cell tumour (DSRCT). The study will assess the feasibility of generating the ATIMP and administering hBRCA84D CAR T cells to patients with r/r RMS, ES or DSRCT.

This description comes directly from the study's public registry record.

Talk to the study team

MIGHTY Trial Coordinator  ·  +4420 7679 9852  ·  ctc.mighty@ucl.ac.uk

Karin Straathof

Always discuss trial participation with your own doctor first.

Locations (2)

Great Ormond Street HospitalLondon, United KingdomRecruiting
University College London HospitalLondon, United KingdomRecruiting

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