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Study identifier: NCT07745790 Synced from ClinicalTrials.gov · August 06, 2026
● Study status: Not Yet Recruiting

Safety and Efficacy of Multimodal Thermal Therapy (MTT) Combined With KRAS G12V mRNA Vaccine, S-1, and Sintilimab in Patients With Metastatic Pancreatic Cancer

Condition: Pancreatic Ductal Adenocarcinoma · Liver Neoplasms · Lung Neoplasms  ·  Sponsor: Ruijin Hospital

PhasePhase 2
Planned participants20
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is a single-arm, single-center, exploratory clinical study. A total of 20 participants with metastatic pancreatic ductal adenocarcinoma (with liver or lung metastasis) who have experienced disease progression after or are intolerant to standard first-line chemotherapy (based on the AG regimen \[Albumin-bound Paclitaxel plus Gemcitabine\]) will be enrolled.The study aims to evaluate the safety, efficacy, and underlying immunological mechanisms of Multimodal Thermal Therapy (MTT) combined with a KRAS G12V mRNA vaccine, S-1, and Sintilimab.

This description comes directly from the study's public registry record.

Talk to the study team

baiyong shen  ·  +86 18817821319  ·  shenby@shsmu.edu.cn

Always discuss trial participation with your own doctor first.

Locations (1)

Ruijin Hospital, Shanghai Jiao Tong University School of MedicineShanghai, Shanghai Municipality, China

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