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Study identifier: NCT07733089 Synced from ClinicalTrials.gov · August 08, 2026
● Study status: Recruiting

A Trial to Understand How Safe and Well Tolerated ZP9830 is and How it Works in People With Plaque Psoriasis Over an 8-week Treatment Period

Condition: Plaque Psoriasis  ·  Sponsor: Zealand Pharma

PhasePhase 1
Planned participants32
Who can joinAll sexes, 18 Years to 60 Years
Healthy volunteersNoCheck eligibility criteria ↓
WhereLeiden, South Holland, Netherlands

Interested? Contact the study team ↓

For sponsors, CROs & site teams
Professional view of this study — listed sites, countries and recruiting context from the public registry. Everything below is written for patients and caregivers.See where this study is running →

About this study

The purpose of this trial is to investigate the effects of repeated administration of ZP9830 for 8 weeks in participants with plaque psoriasis. Here, the primary aim is to evaluate safety and tolerability of ZP9830, the secondary aims are to test clinical efficacy and pharmacokinetics, and lastly the exploratory aim is to test the pharmacodynamic effects of ZP9830 treatment.

This description comes directly from the study's public registry record.

Talk to the study team

Clinical Operations  ·  +45 88 77 36 00  ·  clinicaltrials@zealandpharma.com

There is no obligation to join — the study team can answer your questions about taking part.

Always discuss trial participation with your own doctor first.

Full eligibility criteria (exactly as the study team wrote them)

Inclusion Criteria: * Participants with a confirmed diagnosis of psoriasis (stable plaque psoriasis ≥ 2 months). * Participants who have ≥ 2 vulgar psoriatic plaques. * BMI within the range 18.0-35.0 kg/m2 (inclusive). * Further inclusion criteria apply. Exclusion Criteria: * Erythrodermic, predominantly guttate, exclusively palmar/plantar, or generalized pustular psoriasis. * Current drug-induced or aggravated psoriasis (e.g., a new onset of psoriasis or an exacerbation of psoriasis from beta-blockers, calcium-channel blockers, or lithium carbonate). * Any clinically significant abnormalities, as judged by the investigator, in laboratory test results (including hematology, biochemistry, and urinalysis). * Any clinically significant abnormal findings during the standardized neurological examination conducted at screening. * Use of any concurrent systemic medications that could affect psoriasis or psoriasis evaluation, including corticosteroids, retinoids, cyclosporine, methotrexate, PDE4s (phosphodiesterase 4), or biologic agents within 30 days prior to IMP administration or planned to use during the course of the trial. * Use of concurrent topical medications containing corticosteroids, retinoids, calcitriol or other topical medication relevant to psoriasis treatment (must be discontinued at least 2 weeks prior to baseline). * Use of any biologic or advance systemic therapies for any autoimmune disease within the last 12 months. * Use of UVA, PUVA, or UVB therapy and tanning beds within 4 weeks of baseline or during trial participation. * Further exclusion criteria apply.

Reproduced word-for-word from the public registry record — the study team can answer questions about it.

Locations (1)

Centre for Human Drug ResearchLeiden, South Holland, NetherlandsRecruiting

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Leiden

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