EICHORCondition: Healthy · Sponsor: Merck Sharp & Dohme LLC
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Researchers are looking for new weight loss medicines for people with higher body weight. The trial medicine, MK-4082, is different from similar weight loss medicines because people take it as a pill instead of an injection. Before giving a trial medicine to participants with a health condition, researchers first do trials in healthy participants to find a safe dose level (amount) of the trial medicine. The goal of this study is to learn what happens to MK-4082 in a person's body over time. Researchers will compare what happens to levels of MK-4082 in people's blood when it is taken alone (Part 1, Period 1 and Part 2) and in combination with (Part 1, Period 2) another medicine called diltiazem. Researchers also want to learn about the safety of MK-4082 taken with and without diltiazem and if people tolerate them.
This description comes directly from the study's public registry record.
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Inclusion Criteria: The main inclusion criteria include but are not limited to the following: * Is in good health * Body mass index (BMI) between 18 and 32 kg/m\^2, inclusive Exclusion Criteria: The main exclusion criteria include but are not limited to the following: * Has a history of previous surgical treatment for obesity that may induce malabsorption, history of bowel resection \>20 cm, any malabsorption disorder, severe gastroparesis, or any GI procedure for weight loss * Had a recent pancreatitis or has a history of pancreatitis
Reproduced word-for-word from the public registry record — the study team can answer questions about it.
| Anaheim Clinical Trials ( Site 0001) | Anaheim, California, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07697625