EICHORCondition: Cystic Fibrosis (CF) · Sponsor: Nicole Hamblett
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The REACT trial consists of two parallel, randomized studies; the Hypertonic Saline Study and the Dornase Alfa Study. Health outcomes among people with cystic fibrosis (CF) have been steadily improving, most recently with the advent of highly effective modulator therapy (HEMT). While therapies like hypertonic saline (HS) and dornase alfa (DA) improved outcomes in the past, they are often burdensome. Now that almost 90% of the North American CF population is being treated with elexacaftor/tezacaftor/ivacaftor (ETI) or vanzacaftor/tezacaftor/deutivacaftor (VTD), this trial will evaluate whether these newer treatments make daily HS or DA unnecessary. The trial begins with a 6-week run-in period where participants continue ETI or VTD but stop using HS and DA. Eligible participants are then assigned to either the HS Study or the DA Study for one year. Within those groups, they are randomized to either daily use of HS or DA or as needed use only during respiratory illnesses. The study aims to find out if lung health is similar between children and teens taking HEMT who use HS or DA treatments daily and those who use HS or DA treatments only when they are sick.
This description comes directly from the study's public registry record.
Rachael Buckingham · 206-884-7517 · rachael.buckingham@seattlechildrens.org
Anna Mead · anna.mead@seattlechildrens.org
Always discuss trial participation with your own doctor first.
| The Children's Hospital Alabama, University of Alabama at Birmingham | Birmingham, Alabama, United States | — |
| Tucson Cystic Fibrosis Center | Tucson, Arizona, United States | — |
| Childrens Hospital Los Angeles | Los Angeles, California, United States | — |
| CHOC Children's Hospital | Orange, California, United States | — |
| Stanford University Medical Center | Palo Alto, California, United States | — |
| Children's Hospital Colorado | Aurora, Colorado, United States | — |
| All Children's Hospital | St. Petersburg, Florida, United States | — |
| Children's Healthcare of Atlanta and Emory University | Atlanta, Georgia, United States | — |
| Ann & Robert H. Lurie Children's Hospital of Chicago | Chicago, Illinois, United States | — |
| Riley Hospital for Children | Indianapolis, Indiana, United States | — |
| University of Iowa | Iowa City, Iowa, United States | — |
| John Hopkins Hospital | Baltimore, Maryland, United States | — |
+ 27 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT07696338