EICHORCondition: Dry Eye · Sponsor: Beijing Tongren Hospital
This is a prospective, multicenter, open-label, randomized controlled trial designed to evaluate the efficacy and safety of perfluorohexyloctane (PFHO) eye drops (Hengqin®, Chengdu Shengdi Pharmaceutical Co., Ltd.) compared with 0.1% sodium hyaluronate eye drops in patients with video display terminal (VDT)-associated dry eye. Participants aged 18-70 years with mild to moderate dry eye (confirmed by Chinese Dry Eye Expert Consensus 2020 criteria) who use video display terminal for more than 6 hours/day and at least 5 days/week for more than 1 year will be enrolled. A total of 159 subjects will be randomized in a 2:1 ratio to the experimental group (PFHO eye drops, n=106) or control group (0.1% sodium hyaluronate eye drops, n=53), both administered 1 drop/eye, 4 times daily (3-5 hour intervals), bilaterally, for 8 weeks. The primary endpoint is the change from baseline in fluorescein tear film break-up time (FBUT) at Week 8. Secondary endpoints include FBUT changes at Weeks 2 and 4, standard patient evaluation of eye dryness（SPEED） questionnaire score changes, total corneal fluorescein staining (tCFS), partial blink rate (PBR), non-invasive tear film break-up time (NIBUT), lipid layer thickness (LLT), meibomian gland secretion quality score, and This is a prospective, multicenter, open-label, randomized controlled trial designed to evaluate the efficacy and safety of perfluorohexyloctane (PFHO) eye drops (Hengqin®, Chengdu Shengdi Pharmaceutical Co., Ltd.) compared with 0.1%…
This description comes directly from the study's public registry record.
Jin Yuan · 010-58366699 · yuanjincornea@126.com
Always discuss trial participation with your own doctor first.
| Beijing Anzhen Hospital | Beijing, Beijing Municipality, China | — |
| Beijing Aier-Intech Eye Hospital | Beijing, China | — |
| Chinese PLA General Hospital | Beijing, China | — |
| Peking Union Medical College Hospital | Beijing, China | — |
| Guangdong Provincial People's Hospital | Guangzhou, China | — |
| Sun Yat-sen Memorial Hospital | Guangzhou, China | — |
| Eye & ENT Hospital of Fudan University | Shanghai, China | — |
| Xi'an Fourth Hospital | Xi'an, China | — |
| Zhongshan City People's Hospital | Zhongshan, China | — |
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Source record: clinicaltrials.gov/study/NCT07679685