Condition: Diabetes Mellitus, Type 2 · Sponsor: Novo Nordisk A/S
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The study is testing UBT251 in participants with type 2 diabetes. The purpose of this clinical study is to find out if UBT251 is effective and safe for treating participants with type 2 diabetes. Participants will either get UBT251, UBT251 placebo, semaglutide, or semaglutide placebo. Which treatment participants get is decided by chance. UBT251 is the treatment being tested and is not yet available for doctors to prescribe, while semaglutide is a medicine used to treat type 2 diabetes that doctors can already prescribe.
This description comes directly from the study's public registry record.
Novo Nordisk · (+1) 866-867-7178 · clinicaltrials@novonordisk.com
There is no obligation to join — the study team can answer your questions about taking part.
Always discuss trial participation with your own doctor first.
Inclusion Criteria: * Male or female (sex assigned at birth, inclusive of all gender identities). * Age 18-75 years (both inclusive) at the time of signing the informed consent. * Diagnosed with type 2 diabetes greater than or equal to (≥) 180 days before screening. * Stable daily dose(s) ≥ 90 days before screening of the following antidiabetic drug(s) or combination regimen(s) at effective or maximum tolerated dose as judged by the investigator: metformin with or without sodium-glucose cotransporter-2 (SGLT2) inhibitor. * HbA1c of 7.0-10.5 percent (%) (53-91 millimoles per mole (mmol/mol)) (both inclusive) as assessed by central laboratory at screening. * Body mass index between 25.0 kg/m\^2 and 50.0 kg/m\^2 (both inclusive) at screening. Exclusion Criteria: * Treatment with any medication (prescription or over-the counter) or alternative remedies for the indication of diabetes or obesity other than stated in the inclusion criteria within 90 days before screening. However, short term insulin treatment for a maximum of 14 consecutive days and prior insulin treatment for gestational diabetes are allowed. * Uncontrolled and potentially unstable diabetic retinopathy or maculopathy. Verified by an eye examination performed within 90 days before screening or in the period between screening and randomisation. Pharmacological pupil-dilation is a requirement unless using a digital fundus photography camera specified for non-dilated examination. * Known hypoglycaemic unawareness as indicated by the investigator according to Clarke's questionnaire, question 8.
Reproduced word-for-word from the public registry record — the study team can answer questions about it.
| Flourish Research | Birmingham, Alabama, United States | Recruiting |
| Ark Clinical Research | Fountain Valley, California, United States | Recruiting |
| Ark Clinical Research | Long Beach, California, United States | Recruiting |
| Los Angeles Institute for Metabolic Research | Los Angeles, California, United States | Recruiting |
| Catalina Research Institute, LLC | Montclair, California, United States | Recruiting |
| Encore Medical Research LLC | Hollywood, Florida, United States | Recruiting |
| South Broward Research LLC | Miramar, Florida, United States | Recruiting |
| Encore Medical Research of Weston | Weston, Florida, United States | Recruiting |
| Midwest Inst For Clin Res | Indianapolis, Indiana, United States | Not Yet Recruiting |
| Cotton O'Neil Diabetes & Endocrinology | Topeka, Kansas, United States | Recruiting |
| MD Medical Research | Oxon Hill, Maryland, United States | Recruiting |
| PharmQuest | Greensboro, North Carolina, United States | Not Yet Recruiting |
+ 57 more locations — full list on the registry record.
This study lists sites in the areas below. Each link shows other recruiting studies near that city, from the public registry record.
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