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Study identifier: NCT07634471 Synced from ClinicalTrials.gov · August 07, 2026
● Study status: Recruiting

A Clinical Trial of MK-1045 and Rituximab in People With Follicular Lymphoma (MK-1045-007)

Condition: Follicular Lymphoma  ·  Sponsor: Merck Sharp & Dohme LLC

PhasePhase 2/Phase 3
Planned participants960
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

Sponsor, CRO or site team? See where this study is running → — listed sites, countries and recruiting context. Everything below is written for patients and caregivers.

About this study

Researchers are looking for new ways to treat follicular lymphoma (FL). A standard (usual) treatment for FL includes a targeted therapy called rituximab and chemotherapy. In this study, researchers want to learn if giving a study medicine called MK-1045 and rituximab can treat FL. MK-1045 is a type of treatment called immunotherapy. The goals of this study are to learn: * About the safety of MK-1045 and rituximab, and if people tolerate them when given together * If people who receive MK-1045 and rituximab have the cancer go away * If people who receive MK-1045 and rituximab live longer without their cancer getting worse compared to those who receive standard treatment (rituximab and chemotherapy)

This description comes directly from the study's public registry record.

Talk to the study team

Toll Free Number  ·  1-888-577-8839  ·  Trialsites@msd.com

Always discuss trial participation with your own doctor first.

Locations (16)

Duke Cancer Center Clinic 1B/C Onc/Heme ( Site 1307)Durham, North Carolina, United StatesRecruiting
SCRI Oncology Partners ( Site 7000)Nashville, Tennessee, United StatesRecruiting
Sanatorio Nuestra Senora del Rosario ( Site 0104)Rosario, Santa Fe Province, ArgentinaRecruiting
Hadassah Medical Center ( Site 0701)Jerusalem, IsraelRecruiting
Sheba Medical Center ( Site 0702)Ramat Gan, IsraelRecruiting
Sourasky Medical Center ( Site 0704)Tel Aviv, IsraelRecruiting
Institut Català d'Oncologia (ICO) - Badalona ( Site 0904)Badalona, Barcelona, SpainRecruiting
Hospital Virgen de la Victoria ( Site 0905)Málaga, Malaga, SpainRecruiting
Hospital Universitari Vall de Hebron ( Site 0903)Barcelona, SpainRecruiting
Hospital Universitario Gregorio Maranon ( Site 0902)Madrid, SpainRecruiting
Hospital Universitario de Salamanca ( Site 0906)Salamanca, SpainRecruiting
National Taiwan University Hospital ( Site 1001)Taipei, TaiwanRecruiting

+ 4 more locations — full list on the registry record.

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