EICHORCondition: Parkinson Disease (PD) · PARKINSON DISEASE (Disorder) · Gut Microbiome · Sponsor: Duke University
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The purpose of this research study is to identify the role that the gut-brain axis, the group of nerves that connect the brain and gut, plays in Parkinson's disease (PD). The National Institute of Diabetes and Digestive and Kidney Diseases is sponsoring this research study. During this study, specific groups of participants, also known as "cohorts", will be identified based on the severity of their PD. There will also be a cohort enrolling participants who do not have Parkinson's and a cohort enrolling participants that are at risk for developing PD. Each of these cohorts will be compared to the others to assess the differences in the gut-brain connection. Participants in this study will: * meet with a medical provider * answer questionnaires * give samples of blood, stool, and saliva * have X-rays taken while swallowing different foods (swallowing study) * have X-rays taken to see how long it takes markers to move through their colon (colon transit study) * have a flexible sigmoidoscopy, where a doctor looks inside the lower part of the colon and takes small tissue samples (biopsies) from the mucosa (lining) * have samples taken of their skin * have an anorectal manometry and a balloon expulsion test, where a small tube and balloon are placed in the rectum to measure muscle function. Participation in the study will last up to 24 months (2 years).
This description comes directly from the study's public registry record.
Contact details are listed per location below or on the registry record.
Always discuss trial participation with your own doctor first.
| Stanford University | Stanford, California, United States | Not Yet Recruiting |
| Rush University | Chicago, Illinois, United States | Not Yet Recruiting |
| University of Chicago | Chicago, Illinois, United States | Not Yet Recruiting |
| Massachusetts General Hospital | Boston, Massachusetts, United States | Not Yet Recruiting |
| Mayo Clinic | Rochester, Minnesota, United States | Recruiting |
| Columbia University | New York, New York, United States | Not Yet Recruiting |
| Medical University of South Carolina | Charleston, South Carolina, United States | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT07567794