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Study identifier: NCT07489495 Synced from ClinicalTrials.gov · August 05, 2026 (live refresh unavailable — showing our last good copy)
● Study status: Recruiting

A Clinical Study of Belzutifan (MK-6482) and Zanzalintinib in People With Renal Cell Carcinoma (RCC) (LITESPARK-034/LS-034/MK-6482-034)

Condition: Carcinoma, Renal Cell  ·  Sponsor: Merck Sharp & Dohme LLC

PhasePhase 3
Planned participants758
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

Sponsor, CRO or site team? See where this study is running → — listed sites, countries and recruiting context. Everything below is written for patients and caregivers.

About this study

Researchers are looking for new ways to treat advanced renal cell carcinoma (RCC). A standard (usual) treatment for certain people with RCC is belzutifan (a study medicine), which is a targeted therapy. Targeted therapy is a treatment that works to control how specific types of cancer cells grow and spread. Researchers want to learn if adding another targeted therapy called zanzalintinib (another study medicine) can treat more people with advanced RCC than belzutifan alone. The goal of this study is to learn if people who receive belzutifan and zanzalintinib live longer overall and without the cancer getting worse compared to people who receive belzutifan and placebo.

This description comes directly from the study's public registry record.

Talk to the study team

Toll Free Number  ·  1-888-577-8839  ·  Trialsites@msd.com

Always discuss trial participation with your own doctor first.

Locations (66)

Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital ( Site 0102)Marietta, Georgia, United StatesRecruiting
The West Clinic, P.C. ( Site 0115)Germantown, Tennessee, United StatesRecruiting
Centro Oncologico Korben ( Site 0254)CABA, Buenos Aires, ArgentinaRecruiting
Hospital Italiano de Buenos Aires ( Site 0253)Ciudad de Buenos Aires, Buenos Aires, ArgentinaRecruiting
Instituto de Investigaciones Clinicas Mar del Plata ( Site 0250)Mar del Plata, Buenos Aires, ArgentinaRecruiting
Centro Privado de RMI Río Cuarto S.A. II ( Site 0255)Río Cuarto, Córdoba Province, ArgentinaRecruiting
Sanatorio Parque ( Site 0251)Rosario, Santa Fe Province, ArgentinaRecruiting
Instituto de Oncología de Rosario ( Site 0257)Rosario, Santa Fe Province, ArgentinaRecruiting
Instituto Alexander Fleming ( Site 0252)CABA, ArgentinaRecruiting
Centro Oncológico Riojano Integral ( Site 0256)La Rioja, ArgentinaRecruiting
COE (Centro Oncológico de Excelencia) ( Site 0259)San Juan, ArgentinaRecruiting
Macquarie University ( Site 2700)Macquarie University, New South Wales, AustraliaSuspended

+ 54 more locations — full list on the registry record.

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