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Study identifier: NCT07426757 Synced from ClinicalTrials.gov · August 07, 2026
● Study status: Recruiting

An Open-Label Study to Evaluate PF-07994525 in Participants With Advanced Cancers

Condition: Advanced Malignancies · Advanced Cancer  ·  Sponsor: Pfizer

PhasePhase 1
Planned participants120
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

Sponsor, CRO or site team? See where this study is running → — listed sites, countries and recruiting context. Everything below is written for patients and caregivers.

About this study

This is an open-label, dose escalation and dose expansion study evaluating the safety, tolerability, Pharmacokinetic (PK), Pharmacodynamic (PD), and antitumor activity of PF-07994525 in participants with R/R MM. The study will consist of 2 parts: Part 1 (Dose Escalation) will consist of PF-07994525 dose escalation to assess the safety, tolerability, and preliminary antitumor activity in participants with R/R MM. In Part 2 (Dose expansion), PF-07994525 may be evaluated in additional participants with R/R MM to further assess safety, PK, PD, and preliminary anti-tumor activity.

This description comes directly from the study's public registry record.

Talk to the study team

Pfizer CT.gov Call Center  ·  1-800-718-1021  ·  ClinicalTrials.gov_Inquiries@pfizer.com

Always discuss trial participation with your own doctor first.

Locations (18)

Sylvester Comprehensive Cancer Center- The Lennar Foundation Medical CenterCoral Gables, Florida, United StatesNot Yet Recruiting
Sylvester Comprehensive Cancer Center - Coral SpringsCoral Springs, Florida, United StatesNot Yet Recruiting
University of Miami Hospital and Clinics - Deerfield BeachDeerfield Beach, Florida, United StatesNot Yet Recruiting
University of Miami Hospital and Clinics - DoralDoral, Florida, United StatesNot Yet Recruiting
Sylvester Comprehensive Cancer Center - HollywoodHollywood, Florida, United StatesNot Yet Recruiting
Sylvester Comprehensive Cancer CenterMiami, Florida, United StatesNot Yet Recruiting
University of Miami Hospital and ClinicsMiami, Florida, United StatesNot Yet Recruiting
Sylvester Comprehensive Cancer Center- KendallMiami, Florida, United StatesNot Yet Recruiting
Sylvester Comprehensive Cancer Center - Sole MiaNorth Miami, Florida, United StatesNot Yet Recruiting
Sylvester Comprehensive Cancer Center - PlantationPlantation, Florida, United StatesNot Yet Recruiting
Emory University Hospital MidtownAtlanta, Georgia, United StatesRecruiting
Emory University HospitalAtlanta, Georgia, United StatesRecruiting

+ 6 more locations — full list on the registry record.

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