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Study identifier: NCT07365995 Synced from ClinicalTrials.gov · August 07, 2026
● Study status: Recruiting

A Phase III Trial of BNT324 Versus Docetaxel in Metastatic Castration-resistant Prostate Cancer

Condition: Metastatic Castration-resistant Prostate Cancer  ·  Sponsor: BioNTech SE

PhasePhase 3
Planned participants736
Who can joinMale, 18 Years to no upper limit
Healthy volunteersNo

Sponsor, CRO or site team? See where this study is running → — listed sites, countries and recruiting context. Everything below is written for patients and caregivers.

About this study

This study will test whether BNT324 is safe and works better against metastatic castration-resistant prostate cancer (mCRPC) than the current standard of care (SoC) chemotherapy, which is docetaxel (given together with the steroid medicines prednisone or prednisolone). The study will include participants with mCRPC that have been previously treated with androgen receptor pathway inhibitor, but with no previous taxane-based systematic chemotherapy for mCRPC. The main goals of this study are: * To find out if BNT324 helps participants live longer without their cancer getting worse (radiographic progression-free survival \[rPFS\]). * To find out if BNT324 helps participants live longer overall (overall survival \[OS\]).

This description comes directly from the study's public registry record.

Talk to the study team

BioNTech clinical trials patient information  ·  +49 6131 9084  ·  patients@biontech.de

Always discuss trial participation with your own doctor first.

Locations (15)

Rocky Mountain Cancer CentersAurora, Colorado, United StatesRecruiting
Florida Cancer Specialists- Fort MyersFort Myers, Florida, United StatesRecruiting
Florida Cancer Specialists- St. PetersburgSt. Petersburg, Florida, United StatesRecruiting
Florida Cancer Specialists- West Palm BeachWest Palm Beach, Florida, United StatesRecruiting
Illinois Cancer SpecialistsNiles, Illinois, United StatesRecruiting
Illinois CancerCare PCPeoria, Illinois, United StatesRecruiting
Maryland Oncology HematologyRockville, Maryland, United StatesRecruiting
Oncology/Hematology Care, Inc.Cincinnati, Ohio, United StatesRecruiting
SCRI Oncology PartnersNashville, Tennessee, United StatesRecruiting
Texas Oncology South AustinAustin, Texas, United StatesRecruiting
Texas Oncology Gulf CoastHouston, Texas, United StatesRecruiting
Texas Oncology, P.A. - TylerTyler, Texas, United StatesRecruiting

+ 3 more locations — full list on the registry record.

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