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Study identifier: NCT07360314 Synced from ClinicalTrials.gov · August 06, 2026
● Study status: Recruiting

Anti-Ly6E Exatecan ADC M7437 in Advanced Solid Tumors

Condition: Advanced Solid Tumors  ·  Sponsor: EMD Serono Research & Development Institute, Inc.

PhasePhase 1
Planned participants138
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this first-in-human (FIH) study is to evaluate the safety, tolerability, Pharmacokinetics (PK), and preliminary clinical activity of M7437 in participants with locally advanced or metastatic solid tumors with known Ly6E expression, including non-small cell lung cancer (NSCLC), triple-negative breast cancer (TNBC), epithelial ovarian carcinoma (EOC), squamous cell carcinoma of the head and neck (SCCHN), pancreatic ductal adenocarcinoma (PDAC), and gastric cancer (GC).

This description comes directly from the study's public registry record.

Talk to the study team

US Medical Information  ·  888-275-7376  ·  eMediUSA@emdserono.com

Communication Center  ·  +49 6151 72 5200  ·  service@emdgroup.com

Always discuss trial participation with your own doctor first.

Locations (9)

Yale University - Yale University School of MedicineNew Haven, Connecticut, United StatesNot Yet Recruiting
Carolina BioOncology Institute, LLC - Cancer Therapy and Research CenterHuntersville, North Carolina, United StatesRecruiting
NEXT HoustonGalveston, Texas, United StatesRecruiting
NEXT Oncology - PARENTSan Antonio, Texas, United StatesRecruiting
Princess Margaret Cancer CentreToronto, CanadaRecruiting
BC Cancer - Vancouver - BC Cancer AgencyVancouver, CanadaNot Yet Recruiting
National Cancer Center HospitalTokyo, JapanRecruiting
Hospital Universitari Vall d'Hebron - VHIO - Oncology - Phase I UnitBarcelona, SpainNot Yet Recruiting
NEXT Madrid - Hospital Universitario Quironsalud MadridMadrid, SpainNot Yet Recruiting

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