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Study identifier: NCT07286578 Synced from ClinicalTrials.gov · August 07, 2026
● Study status: Recruiting

A Prospective, Multicenter, Randomized Controlled Trial to Investigate the Value of Coronary CT Angiography in the Understanding and Management of Coronary Calcium (The Optimal Trial)

Condition: Cardiovascular Diseases · Myocardial Ischemia · Heart Diseases  ·  Sponsor: Fundación EPIC

PhaseNA
Planned participants700
Who can joinAll sexes, 18 Years to 85 Years
Healthy volunteersNo

Sponsor, CRO or site team? See where this study is running → — listed sites, countries and recruiting context. Everything below is written for patients and caregivers.

About this study

The OPTIMAL randomized clinical trial has been designed to compare two imaging strategies and to test the hypothesis that a calcium modification strategy informed by coronary CT angiography (CCTA) will improve procedural efficiency and effectiveness compared with the current standard of care (IVUS-guided PCI) while achieving similar clinical outcomes in patients with hemodynamically significant calcified coronary artery disease.

This description comes directly from the study's public registry record.

Talk to the study team

CAROLINA FOCELLA  ·  001 917 753 6695  ·  cfocella@crf.org

CARLOS COLLET, MD,PhD  ·  001 917 753 6695  ·  carloscollet@gmail.com

Always discuss trial participation with your own doctor first.

Locations (14)

Bringham and Women's HospitalBoston, Massachusetts, United StatesNot Yet Recruiting
Minneapolis Heart InstituteMinneapolis, Minnesota, United StatesNot Yet Recruiting
HACKENSACK MERIDIAN HEALTH, IncJersey City, New Jersey, United StatesNot Yet Recruiting
Columbia University Irving Medical Center/NewYork-Presbyterian HospitalNew York, New York, United StatesNot Yet Recruiting
Weill Medical College of Cornell UniversityNew York, New York, United StatesNot Yet Recruiting
Azorg Hospital, AalstAalst, BelgiumRecruiting
Hospital Universitari Vall HebronBarcelona, SpainRecruiting
Hospital Universitario de LeonLeón, SpainRecruiting
Hospital Universitario La PazMadrid, SpainRecruiting
University Hospitals of Leicester NHS TrustLeicester, United KingdomRecruiting
St Bartholomew's Hospital (Barts Health NHS Trust)London, United KingdomRecruiting
St George's University Hospitals NHS Foundations TrustLondon, United KingdomRecruiting

+ 2 more locations — full list on the registry record.

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