EICHORCondition: Chronic Rhinosinusitis (CRS) · Chronic Rhinosinusitis (CRS) With and Without Nasal Polyps · Sponsor: Polyganics BV
Sponsor, CRO or site team? See where this study is running → — listed sites, countries and recruiting context. Everything below is written for patients and caregivers.
The primary objective of the study is to evaluate the safety and effectiveness of OCEAN as an adjunct aid in wound healing after nasal/sinus surgery and to demonstrate that OCEAN is non-inferior compared to a steroid-eluting sinus stent.
This description comes directly from the study's public registry record.
No contact information is available for this study as per the public registry record.
Always discuss trial participation with your own doctor first.
Inclusion Criteria: 1. Subject is 18 years or older 2. Subject is scheduled to undergo bilateral endoscopic sinus surgery for Chronic Rhinosinusitus with nasal polyps (CRSwNP) or without nasal polyps (CRSsNP) and is indicated for bilateral complete ethmoidectomy (anterior and posterior ethmoidectomy) at a minimum. Additional sinuses may be operated on at the surgeon's discretion. 3. Subject is willing and able to provide informed consent. 4. Subject is willing and able to comply with the investigational plan requirements. 5. Subjects with a pre-operative Lund-MacKay stage of 6 (≥3 per nostril). 6. Subject with a pre-operative Lund-Mackay stage side-to-side difference ≤ 2. 7. Subject of child-bearing potential is not pregnant and agrees to not become pregnant during the course of the study. Exclusion Criteria: 1. Subject with a history of chronic epistaxis or experienced a significant epistaxis event (defined as epistaxis requiring medical intervention) in the past 3 months. 2. Subject with an underlying systemic disorders known to affect the nose (e.g., Wegener's granulomatosis, sarcoidosis, Churg-Strauss syndrome, or other systemic vasculitides). 3. Subject with any bleeding disorder or use of medication increasing bleeding risk, except low-dose aspirin. 4. Subject with a known or suspected allergy to device components. 5. Subject with known hemophilia. 6. Subject with insulin dependent diabetes. 7. Subject with an oral steroid dependent condition. 8. Subject with glaucoma, ocular hypertension, posterior subcapsular cataracts. 9. Subject with a (previous) diagnosis of Samter's Triad (AERD). 10. Subject that requires nasal ointments or creams at time of device placement. 11. Subject with a neurological, medical, psychiatric condition, or social circumstance that would potentially increase risk, interfere with study participation, or confound interpretation of study data. 12. Subject with plans to (or otherwise anticipate the need to) undergo an ENT procedure within the 90-day study follow-up. 13. Subject participating in another clinical research study (within 30 days prior to screening up to 90 days post-operative). 14. Subject that used any form of biologics within 90 days prior to sinus surgery and during follow-up to day 25. 15. Subject that used any form of corticosteroid within 2 weeks prior to sinus surgery.
Reproduced word-for-word from the public registry record — the study team can answer questions about it.
| Colorado ENT & Allergy | Colorado Springs, Colorado, United States | — |
| Emory University | Atlanta, Georgia, United States | — |
| University of Illinois at Chicago | Chicago, Illinois, United States | — |
| Louisiana State University Health at Shreveport | Shreveport, Louisiana, United States | — |
| Centers for Advanced ENT Care | Towson, Maryland, United States | — |
| Medical University of South Carolina | Charleston, South Carolina, United States | — |
| University of Texas Health | Houston, Texas, United States | — |
| Ogden Clinic | Ogden, Utah, United States | — |
| ENT Allergy & Associates | Puyallup, Washington, United States | — |
Get one email when the public record changes — results posted, or the study's status changes. Nothing else, ever.
We email about this public record only. Unsubscribe anytime with one click. Never medical advice. By subscribing you agree to our Terms of Use and Privacy Policy.
This page is independently generated by Eichor from the public ClinicalTrials.gov record and re-synced daily. It is not the sponsor's official website unless claimed. Nothing here is medical advice; eligibility is always determined by the study team — talk to your own doctor first.
Source record: clinicaltrials.gov/study/NCT07286201