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Study identifier: NCT07278336 Synced from ClinicalTrials.gov · August 09, 2026
● Study status: Recruiting

A Study to Assess Adverse Events, Change in Disease Activity and How Intravenous (IV) ABBV901 Moves Through the Body Alone or in Combination With Bevacizumab in Adult Participants With Ovarian Cancer

Condition: Ovarian Cancer  ·  Sponsor: AbbVie

PhasePhase 1
Planned participants219
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNoCheck eligibility criteria ↓
Where17 locations · 6 countries

Interested? Contact the study team ↓

For sponsors, CROs & site teams
Professional view of this study — listed sites, countries and recruiting context from the public registry. Everything below is written for patients and caregivers.See where this study is running →

About this study

Ovarian cancer (OC) is a lethal disease. The purpose of this study is to assess the safety, pharmacokinetics and efficacy of ABBV901, alone or in combination with bevacizumab, in participants with ovarian cancer. ABBV901 is an investigational drug for the treatment of ovarian cancer. This study has 4 Parts (Arms) where participants will receive ABBV-901, alone or in combination with the standard available therapy, bevacizumab. Around 219 participants will be enrolled in the study at approximately 75 sites around the world. In part 1, participants will receive escalating doses of intravenous (IV) ABBV-901 alone. In part 2, participants will receive 1 of 3 doses of IV ABBV-901, alone to determine the optimized dose. In part 3, participants will receive escalating doses of IV ABBV-901, combination with IV bevacizumab. In part 4, participants will receive recommended doses for expansion of IV ABBV-901, combination with IV bevacizumab. The total study duration will be approximately 3 years. There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at a hospital or clinic and may require frequent medical assessments, blood tests, and scans.

This description comes directly from the study's public registry record.

Talk to the study team

ABBVIE CALL CENTER  ·  844-663-3742  ·  abbvieclinicaltrials@abbvie.com

There is no obligation to join — the study team can answer your questions about taking part.

Always discuss trial participation with your own doctor first.

Full eligibility criteria (exactly as the study team wrote them)

Inclusion Criteria: * Diagnosis of an advanced or unresectable malignant high grade serous epithelial ovarian, fallopian tube, and primary peritoneal cancers (EOC), fallopian tube or primary peritoneal cancer by histology (World Health Organization \[WHO\] criteria). * Participants must be considered platinum resistant or platinum ineligible. Platinum resistant disease is defined as radiographic progression within 6 months (up to 182 days) after the last dose of the most recent platinum therapy). * Prior anticancer therapy: * Must have received appropriate standard of care therapy and be appropriate for participation in a Phase I study in the opinion of the investigator. * Platinum-resistant, high grade serous EOC cannot have had more than 2 prior lines of therapy, since the development of platinum resistance or ineligibility. * For participants enrolled in backfill, subjects must provide consent to paired biopsies which are pretreatment and on-treatment tumor biopsies from the same tumor lesion. Exclusion Criteria: * Ovarian Cancer (OC) with histologies other than high grade serous OC including endometrioid, low grade, clear cell, mucinous, or borderline ovarian tumor. * Prior therapy with an antibody-drug conjugate containing a topoisomerase inhibitor. * Prior history of Grade \>= 2 ILD or pneumonitis. * History of interstitial lung disease (ILD) or pneumonitis that required treatment with systemic steroids, or any evidence of active ILD or pneumonitis on Screening chest computed tomography (CT) scan. * Must not have systemically used known strong cytochrome P450 (CYP)3A inhibitors or inducers within 14 days or 5 half-lives of the drug (whichever is shorter) prior to the first dose of the study drug through the end of the DLT observation period. If clinically indicated, strong CYP3A inhibitors and inducers may be used with caution after the dose-limiting toxicity (DLT) period.

Reproduced word-for-word from the public registry record — the study team can answer questions about it.

Locations (17)

Sarah Cannon Research Institute at HealthONE /ID# 278785Denver, Colorado, United StatesRecruiting
University of Chicago Medical Center /ID# 278295Chicago, Illinois, United StatesRecruiting
NEXT Oncology - San Antonio /ID# 278606San Antonio, Texas, United StatesRecruiting
Start Mountain Region /ID# 278609West Valley City, Utah, United StatesRecruiting
Next Virginia /ID# 278607Fairfax, Virginia, United StatesRecruiting
Sun Yat-Sen University Cancer Center /ID# 282505Guangzhou, Guangdong, ChinaNot Yet Recruiting
Qilu Hospital Of Shandong University /ID# 283564Jinan, Shandong, ChinaNot Yet Recruiting
Shandong Cancer Hospital /ID# 283566Jinan, Shandong, ChinaNot Yet Recruiting
Fudan University Shanghai Cancer Center /ID# 282600Shanghai, Shanghai Municipality, ChinaNot Yet Recruiting
The Chaim Sheba Medical Center /ID# 278416Ramat Gan, Tel Aviv, IsraelRecruiting
Rambam Health Care Campus /ID# 278418Haifa, IsraelRecruiting
Hadassah Medical Center-Hebrew University /ID# 278420Jerusalem, IsraelRecruiting

+ 5 more locations — full list on the registry record.

More studies in these areas

This study lists sites in the areas below. Each link shows other recruiting studies near that city, from the public registry record.

DenverChicagoSan AntonioWest Valley City

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