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Study identifier: NCT07153471 Synced from ClinicalTrials.gov · August 07, 2026
● Study status: Recruiting

A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Osteoarthritis (OA) of the Knee

Condition: Osteoarthritis  ·  Sponsor: Eli Lilly and Company

PhasePhase 3
Planned participants800
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The GZPT master protocol will support two independent studies, J2A-MC-GZT1 and J2A-MC-GZT2. Each study will see how well and safely orforglipron works in people with obesity or overweight who have osteoarthritis (OA) of the knee with pain. Participation in the study will last about 74 weeks.

This description comes directly from the study's public registry record.

Talk to the study team

Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or  ·  1-317-615-4559  ·  LillyTrials@Lilly.com

Physicians interested in becoming principal investigators please contact  ·  clinical_inquiry_hub@lilly.com

Always discuss trial participation with your own doctor first.

Locations (96)

Arizona Research CenterPhoenix, Arizona, United StatesRecruiting
AMR ClinicalTempe, Arizona, United StatesRecruiting
Care Access - Huntington BeachHuntington Beach, California, United StatesRecruiting
Care Access - Thousand OaksThousand Oaks, California, United StatesRecruiting
Legacy Clinical TrialsColorado Springs, Colorado, United StatesRecruiting
Chase Medical Research, LLCWaterbury, Connecticut, United StatesRecruiting
Care Access - DecaturDecatur, Georgia, United StatesRecruiting
North Georgia Clinical ResearchWoodstock, Georgia, United StatesRecruiting
Northwestern UniversityChicago, Illinois, United StatesRecruiting
AMR ClinicalNewton, Kansas, United StatesRecruiting
MedVadis Research CorporationWaltham, Massachusetts, United StatesRecruiting
StudyMetrix ResearchCity of Saint Peters, Missouri, United StatesRecruiting

+ 84 more locations — full list on the registry record.

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