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Study identifier: NCT07115329 Synced from ClinicalTrials.gov · August 06, 2026
● Study status: Recruiting

A Phase 2 Study of Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder

Condition: Major Depressive Disorder  ·  Sponsor: Syndeio Biosciences, Inc

PhasePhase 2
Planned participants164
Who can joinAll sexes, 18 Years to 64 Years
Healthy volunteersNo

About this study

The goal of this clinical trial is to learn if zelquistinel works to treat depression in adults. It will also learn about the safety of zelquistinel. The main questions it aims to answer are: Does zelquistinel reduce depression scores in participants compared to participants who take a placebo (a look-alike tablet that contains no zelquistinel1)? What medical problems are observed in participants who take zelquistinel? Participants will take one tablet of zelquistinel or placebo every week for 6 weeks. Participants will visit the clinic every week of the 6 week period to have the severity of their depression evaluated.

This description comes directly from the study's public registry record.

Talk to the study team

Karen Raudibaugh  ·  781-786-1545  ·  karen.raudibaugh@syndeio.bio

Sharon Ortiz  ·  sharon.ortiz@syndeio.bio

Always discuss trial participation with your own doctor first.

Locations (32)

NoesisPharma, LLCPhoenix, Arizona, United StatesRecruiting
Del Sol Research ManagementTucson, Arizona, United StatesRecruiting
Catalina Research Institute, LLCMontclair, California, United StatesRecruiting
Excell Research, IncOceanside, California, United StatesRecruiting
Anderson Clinical ResearchRedlands, California, United StatesRecruiting
Studyops IncSan Francisco, California, United StatesRecruiting
Lumos Clinical Research CenterSan Jose, California, United StatesRecruiting
Sunwise Clinical ResearchWalnut Creek, California, United StatesNot Yet Recruiting
Clinical Neuroscience Solutions, IncJacksonville, Florida, United StatesNot Yet Recruiting
Premier Clinical Research Institute IncMiami, Florida, United StatesNot Yet Recruiting
Aqualane Clinical ResearchNaples, Florida, United StatesRecruiting
EquiPath Health and Research Tampa Bay, LLCRiverview, Florida, United StatesRecruiting

+ 20 more locations — full list on the registry record.

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