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Study identifier: NCT06994806 Synced from ClinicalTrials.gov · August 07, 2026
● Study status: Recruiting

A Study to Investigate the Safety and Efficacy of KQB168 as Monotherapy and in Combination in Participants With Advanced Solid Malignancies

Condition: Solid Tumor Malignancies  ·  Sponsor: Kumquat Biosciences Inc.

PhasePhase 1
Planned participants84
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

Sponsor, CRO or site team? See where this study is running → — listed sites, countries and recruiting context. Everything below is written for patients and caregivers.

About this study

The goal of this clinical trial is to learn if KQB168 works to treat advanced solid tumor cancer in adults. It will also learn about the safety of KQB168. The main questions it aims to answer are: * What is the safe dose of KQB168 by itself or in combination with pembrolizumab? * Does KQB168 alone or in combination with pembrolizumab decrease the size of the tumor? * What happens to KQB168 in the body? Participants will: * Take KQB168 daily, alone or in combination with pembrolizumab * Visit the clinic about 8 times in the first 8 weeks, and then once every 3 weeks after that

This description comes directly from the study's public registry record.

Talk to the study team

Kumquat Clinical Development  ·  (858) 214-2700  ·  kumquatstudies@kumquatbio.com

Always discuss trial participation with your own doctor first.

Locations (15)

Mayo Clinic - PhoenixPhoenix, Arizona, United StatesRecruiting
USC Norris Comprehensive Cancer CenterLos Angeles, California, United StatesRecruiting
Sarah Cannon Cancer Institute at HealthONEDenver, Colorado, United StatesRecruiting
Yale Cancer Center- New HavenNew Haven, Connecticut, United StatesRecruiting
Mayo Clinic - JacksonvilleJacksonville, Florida, United StatesRecruiting
Florida Cancer Specialists - SarasotaSarasota, Florida, United StatesRecruiting
University of IowaIowa City, Iowa, United StatesRecruiting
Mayo Clinic - RochesterRochester, Minnesota, United StatesRecruiting
Cleveland ClinicCleveland, Ohio, United StatesRecruiting
NEXT AustinAustin, Texas, United StatesRecruiting
Mary Crowley Cancer Research CentersDallas, Texas, United StatesRecruiting
UT MD Anderson Cancer Center - HoustonHouston, Texas, United StatesRecruiting

+ 3 more locations — full list on the registry record.

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