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Study identifier: NCT06925737 Synced from ClinicalTrials.gov · August 07, 2026
● Study status: Recruiting

A Clinical Study of Ifinatamab Deruxtecan (I-DXd) in People With Metastatic Prostate Cancer (MK-2400-001)

Condition: Prostate Cancer · Prostatic Neoplasms  ·  Sponsor: Merck Sharp & Dohme LLC

PhasePhase 3
Planned participants1440
Who can joinMale, 18 Years to no upper limit
Healthy volunteersNo

Sponsor, CRO or site team? See where this study is running → — listed sites, countries and recruiting context. Everything below is written for patients and caregivers.

About this study

Researchers are looking for new ways to treat metastatic castration-resistant prostate cancer (mCRPC). Researchers have designed a study medicine called ifinatamab deruxtecan (also called I-DXd or MK-2400) to treat mCRPC. The goal of this study is to learn if people who receive I-DXd live longer overall and live longer without the cancer growing or spreading than people who receive chemotherapy.

This description comes directly from the study's public registry record.

Talk to the study team

Toll Free Number  ·  1-888-577-8839  ·  Trialsites@msd.com

Always discuss trial participation with your own doctor first.

Locations (290)

Mayo Clinic in Arizona - Phoenix ( Site 0044)Phoenix, Arizona, United StatesRecruiting
City of Hope Comprehensive Cancer Center ( Site 0049)Duarte, California, United StatesRecruiting
City of Hope Lennar Foundation Cancer Center ( Site 0059)Irvine, California, United StatesRecruiting
Moores Cancer Center ( Site 0010)La Jolla, California, United StatesRecruiting
Veterans Affairs Long Beach Healthcare System ( Site 0058)Long Beach, California, United StatesRecruiting
Cedars-Sinai Medical Center ( Site 0068)Los Angeles, California, United StatesRecruiting
UCLA Hematology/Oncology - Santa Monica ( Site 0002)Los Angeles, California, United StatesRecruiting
University of California, Irvine (UCI) Health - UC Irvine Medical Center ( Site 0006)Orange, California, United StatesRecruiting
Stanford Cancer Center ( Site 0046)Palo Alto, California, United StatesRecruiting
Rocky Mountain Regional Veterans Affairs Medical Center ( Site 0053)Aurora, Colorado, United StatesRecruiting
Yale-New Haven Hospital-Yale Cancer Center ( Site 0050)New Haven, Connecticut, United StatesRecruiting
Veterans Affairs Connecticut Healthcare System ( Site 0062)West Haven, Connecticut, United StatesRecruiting

+ 278 more locations — full list on the registry record.

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